Chromosomal Localization of the Human C-fms Oncogene

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1983 Sep 24

PMID 6684766

Citations 11

Authors

J Groffen

N Heisterkamp

N Spurr

S Dana

J J Wasmuth

J R Stephenson

Affiliations

Soon will be listed here.

Abstract

A molecular probe was prepared with specificity for the human cellular homologue of transforming sequences represented within the McDonough strain of feline sarcoma virus (v-fms). By analysis of a series of mouse-human somatic cell hybrids containing variable complements of human chromosomes it was possible to assign this human oncogene, designated c-fms, to chromosome 5. Regional localization of c-fms to band q34 on chromosome 5 was accomplished by analysis of Chinese hamster-human cell hybrids containing as their only human components, terminal and interstitial deleted forms of chromosome 5. The localization of c-fms to chromosome 5 (q34) is of interest in view of reports of a specific, apparently interstitial, deletion involving approximately two thirds of the q arm of chromosome 5 in acute myelogenous leukemia cells.

Citing Articles

The William Allan Memorial Award address: Reverse genetics and beyond.

Ruddle F Am J Hum Genet. 1984; 36(5):944-53.

PMID: 6594045 PMC: 1684509.

Human dihydrofolate reductase gene is located in chromosome 5 and is unlinked to the related pseudogenes.

Maurer B, Barker P, Masters J, Ruddle F, Attardi G Proc Natl Acad Sci U S A. 1984; 81(5):1484-8.

PMID: 6584893 PMC: 344861. DOI: 10.1073/pnas.81.5.1484.

Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism.

Anagnou N, OBrien S, Shimada T, Nash W, Chen M, Nienhuis A Proc Natl Acad Sci U S A. 1984; 81(16):5170-4.

PMID: 6089182 PMC: 391659. DOI: 10.1073/pnas.81.16.5170.

Deletion mapping of human chromosome 5 using chromosome-specific DNA probes.

Carlock L, Skarecky D, Dana S, Wasmuth J Am J Hum Genet. 1985; 37(5):839-52.

PMID: 2996334 PMC: 1684692.

The human homologues of Fim1, Fim2/c-Fms, and Fim3, three retroviral integration regions involved in mouse myeloblastic leukemias, are respectively located on chromosomes 6p23, 5q33, and 3q27.

Van Cong N, Fichelson S, Gross M, Sola B, Bordereaux D, De Tand M Hum Genet. 1989; 81(3):257-63.

PMID: 2921036 DOI: 10.1007/BF00279000.

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