Characterization of Sister Chromatid Exchange Induction by 8-methoxypsoralen Plus Near UV Light

Overview

Journal Cytogenet Cell Genet

Publisher Karger

Specialty Genetics

Date 1978 Jan 1

PMID 668416

Citations 14

Authors

S A LATT

K S Loveday

Affiliations

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Abstract

The combination of 8-methoxypsoralen and near UV light is highly effective in inducing sister chromatid exchanges (SCEs) in Chinese hamster ovary cells. Appreciable increases in SCEs can be effected by treatments compatible with cell survival, and effects of a single dose of alkylation persist over multiple generations. Both the frequency and location of SCEs induced at different times within the DNA synthesis period varies in a manner indicating that exchange induction is restricted to regions which replicated during or after DNA damage.

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