Binding Capacity of Testosterone-estradiol-binding Globulin (TeBG), Total and Calculated Unbound Concentrations of Testosterone in Patients with Carcinoma of the Prostate Treated with Orchidectomy or Estrogens

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 1983 Apr 1

PMID 6683289

Authors

J E Damber

B Bergman

R Sodergard

R Tomic

Affiliations

Soon will be listed here.

Abstract

Testosterone-estradiol-binding globulin (TeBG) binding capacity, total estradiol-17 beta and total testosterone were measured in patients with carcinoma of the prostate treated with orchidectomy or estrogens. Comparisons were made with a control group. There was a significant increase in TeBG binding capacity in the group treated with estrogens. Both orchidectomy and estrogen-treatment decreased total testosterone significantly and to the same degree. The concentration of free testosterone was calculated using a new method, and was found to be lower in orchidectomized and estrogen treated patients when compared with the control group. When the two groups under treatment were compared, the calculated free testosterone concentration was significantly lower in the estrogen treated group.

References

BURKE C, Anderson D . Sex-hormone-binding globulin is an oestrogen amplifier. Nature. 1972; 240(5375):38-40. DOI: 10.1038/240038a0. View

Shanbhag V, Sodergard R, Carstensen H, Albertsson P . A new method for the determination of the binding capacity of testosterone-estradiol-binding-globulin in human plasma. J Steroid Biochem. 1973; 4(5):537-50. DOI: 10.1016/0022-4731(73)90070-8. View

Karr J, Wajsman Z, KIRDANI R, Murphy G, Sandberg A . Effects of diethylstilbestrol and estramustine phosphate on serum sex hormone binding globulin and testosterone levels in prostate cancer patients. J Urol. 1980; 124(2):232-6. DOI: 10.1016/s0022-5347(17)55383-5. View

Victor A, Weiner E, Johansson E . Sex hormone binding globulin: the carrier protein for d-norgestrel. J Clin Endocrinol Metab. 1976; 43(1):244-7. DOI: 10.1210/jcem-43-1-244. View

Carstensen H, Backstrom T . A paper chromatographic saturation analysis method for measuring estradiol, testosterone and 5alpha-dihydrotestosterone from the same sample. J Steroid Biochem. 1976; 7(2):145-9. DOI: 10.1016/0022-4731(76)90151-5. View

Robinson M, Thomas B . Effect of hormonal therapy on plasma testosterone levels in prostatic carcinoma. Br Med J. 1971; 4(5784):391-4. PMC: 1799485. DOI: 10.1136/bmj.4.5784.391. View

Leinonen P, Hammond G, Lukkarinen O, Vihko R . Serum sex hormone binding globulin and testosterone binding after estradiol administration, castration, and their combination in men with prostatic carcinoma. Invest Urol. 1979; 17(1):24-7. View

Akpoviroro J, FOTHERBY K . Assay of ethynyloestradiol in human serum and its binding to plasma proteins. J Steroid Biochem. 1980; 13(7):773-9. DOI: 10.1016/0022-4731(80)90228-9. View

Bartsch W, Horst H, Becker H, Nehse G . Sex hormone binding globulin binding capacity, testosterone, 5alpha-dihydrotestosterone, oestradiol and prolactin in plasma of patients with prostatic carcinoma under various types of hormonal treatment. Acta Endocrinol (Copenh). 1977; 85(3):650-64. DOI: 10.1530/acta.0.0850650. View

10.

Lasnitzki I, Franklin H . The influence of serum on uptake, conversion and action of testosterone in rat prostate glands in organ culture. J Endocrinol. 1972; 54(2):333-42. DOI: 10.1677/joe.0.0540333. View

11.

Hammond G, Nisker J, Jones L, Siiteri P . Estimation of the percentage of free steroid in undiluted serum by centrifugal ultrafiltration-dialysis. J Biol Chem. 1980; 255(11):5023-6. View

12.

Sodergard R, Backstrom T, Shanbhag V, Carstensen H . Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem. 1982; 16(6):801-10. DOI: 10.1016/0022-4731(82)90038-3. View

13.

Harper M, Peeling W, Cowley T, Brownsey B, Phillips M, Groom G . Plasma steroid and protein hormone concentrations in patients with prostatic carcinoma, before and during oestrogen therapy. Acta Endocrinol (Copenh). 1976; 81(2):409-26. DOI: 10.1530/acta.0.0810409. View

14.

Damber J, Janson P . The effects of LH, adrenaline and noradrenaline on testicular blood flow and plasma testosterone concentrations in anaesthetized rats. Acta Endocrinol (Copenh). 1978; 88(2):390-6. DOI: 10.1530/acta.0.0880390. View

15.

Doumas B, Watson W, BIGGS H . Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta. 1971; 31(1):87-96. DOI: 10.1016/0009-8981(71)90365-2. View

16.

BAILAR 3rd J, Byar D . Estrogen treatment for cancer of the prostate. Early results with 3 doses of diethylstilbestrol and placebo. Cancer. 1970; 26(2):257-61. DOI: 10.1002/1097-0142(197008)26:2<257::aid-cncr2820260203>3.0.co;2-9. View

17.

Anderson D . Sex-hormone-binding globulin. Clin Endocrinol (Oxf). 1974; 3(1):69-96. DOI: 10.1111/j.1365-2265.1974.tb03298.x. View

18.

Schnorr D, MEBEL M, Dorner G, Stahl F, Rohde W . Endocrine effects of oestrogen treatment in patients with prostatic cancer. Eur Urol. 1976; 2(2):85-8. DOI: 10.1159/000471968. View

19.

Leinonen P . Estrone and estradiol concentrations in the testis and spermatic and peripheral venous blood of elderly men: the influence of estrogen treatment. J Steroid Biochem. 1980; 13(7):737-42. DOI: 10.1016/0022-4731(80)90225-3. View

20.

Kley H, Herrmann J, Morgner K, KRUSKEMPER H . Effects of testosterone oenanthate on plasma concentrations of thyroxine, cortisol, testosterone and hormone binding proteins in patients with hypogonadism. Horm Metab Res. 1973; 5(4):271-4. DOI: 10.1055/s-0028-1093945. View