Stimulation of Antibody Synthesis Induced by Surgical Trauma in Rats

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1978 May 1

PMID 668200

Citations 7

Authors

P Kinnaert

A Mahieu

N Van Geertruyden

Affiliations

Soon will be listed here.

Abstract

The effect of a standard laparatomy on antibody synthesis was studied in Wistar R/A rats recieving an intravenous injection of 10(9) sheep red blood cells (SRBC) during the surgical procedure. Anti-SRBC antibody titres were significantly higher in operated animals than in controls. When SRBC were given 2 hr after the surgical procedure, stimulation of antibody synthesis still persisted, but when the antigen was administered 24 hr after laparotomy, no significant difference could be detected between the operated animals and controls. Surgery also enhances the secondary humoral response.

Citing Articles

[The effect of anaesthesia and surgery on immune function. A review (author's transl)].

Brocker E, Macher E Klin Wochenschr. 1981; 59(23):1297-301.

PMID: 7311397 DOI: 10.1007/BF01711179.

Generation of suppressor cells in mice after surgical trauma.

Wang B, Heacock E, Wu A, Mannick J J Clin Invest. 1980; 66(2):200-9.

PMID: 6447165 PMC: 371699. DOI: 10.1172/JCI109845.

Need for immunologic stimulators during immunosuppression produced by major cancer surgery.

COLE W, Humphrey L Ann Surg. 1985; 202(1):9-20.

PMID: 3893336 PMC: 1250830. DOI: 10.1097/00000658-198507000-00002.

Appearance of spontaneously Ig secreting B cells in human peripheral blood after surgery.

Di Padova F, Di Padova C, Rovagnati P, Tritapepe R Clin Exp Immunol. 1986; 65(3):582-8.

PMID: 3490939 PMC: 1542487.

Spontaneous regression of extramedullary plasmacytoma--a case report.

Arunabh , Gupta S, Bal S, Sarda A, Vijayraghavan M, Shukla N Jpn J Surg. 1988; 18(4):455-9.

PMID: 3172588 DOI: 10.1007/BF02471472.

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