Toxic Polyneuropathy of Shoe Workers in Italy. A Clinical, Neurophysiological and Follow-up Study

Overview

Journal Ital J Neurol Sci

Specialty Neurology

Date 1983 Dec 1

PMID 6674248

Citations 2

Authors

S Passero

N Battistini

R Cioni

F Giannini

C Paradiso

F Battista

F Carboncini

E Sartorelli

Affiliations

Soon will be listed here.

Abstract

Cases of polyneuropathy due to exposure to industrial solvents have been studied at several shoe factories in the province of Siena. After the screening of 654 employees 98 verified cases were detected. Of these, 16 were rated as moderate to severe, 45 as mild, and 37 were minimally involved but with characteristic electrodiagnostic abnormalities. Follow-up study in 53 patients showed that neurological signs and symptoms as well as electrodiagnostic abnormalities continued for years in several patients. In addition, after a year's observation, some patients showed signs of central nervous system dysfunction such as spasticity of the lower limbs and increased deep tendon reflexes. High percentages of commercial n-hexane were found in all the samples of glues and solvents collected from home-workers and from factories where cases of polyneuropathy occurred.

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References

Gaffuri E, Perbellini L . [Update on the neurotoxicity of n-hexane]. Med Lav. 1980; 71(3):195-8. View

Montesanti V, Liso N . [Long-term results of polyneuropathies from industrial glues. Clinical electromyographic observation of 10 cases]. Med Lav. 1981; 72(2):107-12. View

Carpenter S, Karpati G, Andermann F, Gold R . Giant axonal neuropathy. A clinically and morphologically distinct neurological disease. Arch Neurol. 1974; 31(5):312-6. DOI: 10.1001/archneur.1974.00490410060005. View

AMBROSETTO C . [On certain polyneuritic manifestations connected with probable percutaneous absorption of tri-orthocresylphosphate]. Minerva Med. 1968; 59(78):4078. View

Goto I, Matsumura M, Inoue N, Murai Y, Shida K . Toxic polyneuropathy due to glue sniffing. J Neurol Neurosurg Psychiatry. 1974; 37(7):848-53. PMC: 494793. DOI: 10.1136/jnnp.37.7.848. View

Pinelli P, Tonali P . [SERIAL ELECTROMYOGRAPHIC STUDIES OF POLYNEURITIS. I. ON A CASE OF MOTOR POLYNEURITIS (POLYNEURITIS OF SHOEMAKERS) TREATED WITH VITAMIN DISINTOXICATING THERAPY]. Riv Patol Nerv Ment. 1964; 85:345-85. View

Giuliano G, Ronchi O, Rossi L, Focardi L . [Toxic polyneuropathy in shoe-industry workers. A longitudinal electromyographic study (author's transl)]. Lav Um. 1975; 27(2):35-41. View

Gonzalez E, Downey J . Polyneuropathy in a glue sniffer. Arch Phys Med Rehabil. 1972; 53(7):333-7. View

VIGLIANI E . [Clinical observations on 47 cases of motor polyneuritis manifested in workers handling adhesives and glues]. Minerva Med. 1968; 59(78):4075-6. View

10.

Cosi V, Faggi L, Cavalleri A . [Polyneuritis in the shoe industry (clinicial, electromyographic and biohumoral study)]. Riv Neurobiol. 1973; 19(1-2):5-107. View

11.

CAVANAGH J . PERIPHERAL NERVE CHANGES IN ORTHO-CRESYL PHOSPHATE POISONING IN THE CAT. J Pathol Bacteriol. 1964; 87:365-83. DOI: 10.1002/path.1700870217. View

12.

Schaumburg H, Spencer P . Degeneration in central and peripheral nervous systems produced by pure n-hexane: an experimental study. Brain. 1976; 99(2):183-92. DOI: 10.1093/brain/99.2.183. View

13.

SEPE O, Tecce V, Pomicino P, De Rosa L . [Biology and prespects of prevention of glue-induced polyneuropathies]. Acta Neurol (Napoli). 1973; 28(6):669-72. View

14.

Herskowitz A, Ishii N, Schaumburg H . N-hexane neuropathy. A syndrome occurring as a result of industrial exposure. N Engl J Med. 1971; 285(2):82-5. DOI: 10.1056/NEJM197107082850204. View

15.

Spencer P, Schaumburg H . Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone. J Neurol Neurosurg Psychiatry. 1975; 38(8):771-5. PMC: 492070. DOI: 10.1136/jnnp.38.8.771. View

16.

DiVincenzo G, KAPLAN C, Dedinas J . Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance. Toxicol Appl Pharmacol. 1976; 36(3):511-22. DOI: 10.1016/0041-008x(76)90230-1. View

17.

Leoni G . [The problem of polyneuritis attributed to industrial adhesives]. Riv Sper Freniatr Med Leg Alien Ment. 1967; 91(4):1010-29. View

18.

Shirabe T, Tsuda T, Terao A, Araki S . Toxic polyneuropathy due to glue-sniffing. Report of two cases with a light and electron-microscopic study of the peripheral nerves and muscles. J Neurol Sci. 1974; 21(1):101-13. DOI: 10.1016/0022-510x(74)90110-5. View

19.

Mendell J, Saida K, Ganansia M, Jackson D, Weiss H, GARDIER R . Toxic polyneuropathy produced by methyl N-butyl ketone. Science. 1974; 185(4153):787-9. DOI: 10.1126/science.185.4153.787. View

20.

Towfighi J, Gonatas N, Pleasure D, Cooper H, McCree L . Glue sniffer's neuropathy. Neurology. 1976; 26(3):238-43. DOI: 10.1212/wnl.26.3.238. View