Mobilization of Aged Cadmium Deposits by Dithiocarbamates

Overview

Journal Arch Toxicol

Specialty Toxicology

Date 1983 Nov 1

PMID 6661031

Citations 7

Authors

L A Shinobu

S G Jones

M M Jones

Affiliations

Soon will be listed here.

Abstract

Mice with chronic cadmium intoxication were given low levels (0.6 mm/kg) of several dithiocarbamates (parent compounds: dihydroxyethylamine, iminodiacetic acid, methylhydroxyethylamine and sarcosine) in an attempt to reduce the cadmium present in the liver and kidney. Comparing the results with those obtained with the less polar sodium diethyldithiocarbamate (NaDDTC), only ammonium di(hydroxyethyl)dithiocarbamate (NH4DHE-DTC) possessed a similar ability to reduce kidney cadmium levels. Under the experimental conditions employed, the reduction obtained with NH4DHE-DTC was less than that effected by a comparable dose of NaDDTC. A subsequent dose-dependence study showed, however, that sodium di(hydroxyethyl)dithiocarbamate (NaDHE-DTC) is quite effective at higher dosage levels (up to 5.5 mmoles/kg) where substantial reductions in both kidney (89% mobilization) and liver (38% mobilization) stores of cadmium were observed. High doses of the NaDHE-DTC are well tolerated as the LD50 of this compound in mice is greater than 19.8 mmoles/kg.

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References

GALE G, Atkins L, Walker Jr E, Smith A . Factors influencing cadmium mobilization by diethyldithiocarbamate: chelator dose, cadmium burden, and sex. Ann Clin Lab Sci. 1983; 13(2):107-14. View

Gilman A, PHILIPS F . The treatment of acute cadmium intoxication in rabbits with 2,3-dimercaptopropanol (BAL) and other mercaptans. J Pharmacol Exp Ther. 2010; 87(4 Suppl):85-101. View

Von Burg R, Smith J . Biliary mobilization of cadmium by 2,3-dimercaptopropanol and some related compounds. J Toxicol Environ Health. 1980; 6(1):75-85. DOI: 10.1080/15287398009529832. View

Cherian M, Rodgers K . Chelation of cadmium from metallothionein in vivo and its excretion in rats repeatedly injected with cadmium chloride. J Pharmacol Exp Ther. 1982; 222(3):699-704. View

Sunderman F, SUNDERMAN Jr F . Nickel poisoning. VIII. Dithiocarb: a new therapeutic agent for persons exposed to nickel carbonyl. Am J Med Sci. 1958; 236(1):26-31. DOI: 10.1097/00000441-195807000-00003. View

Jones S, Basinger M, Jones M, Gibbs S . A comparison of diethyldithiocarbamate and EDTA as antidotes for acute cadmium intoxication. Res Commun Chem Pathol Pharmacol. 1982; 38(2):271-8. View

Cherian M . Biliary excretion of cadmium in rat. VI. Mobilization of cadmium from metallothionein by 2,3-dimercaptopropanol. J Toxicol Environ Health. 1980; 6(2):393-401. DOI: 10.1080/15287398009529859. View

Cherian M . Biliary excretion of cadmium in rat. III. Effects of chelating agents and change in intracellular thiol content on biliary transport and tissue distribution of cadmium. J Toxicol Environ Health. 1980; 6(2):379-91. DOI: 10.1080/15287398009529858. View

DALHAMN T, Friberg L . Dimercaprol (2, 3-dimercaptopropanol) in chronic cadmium poisoning. Acta Pharmacol Toxicol (Copenh). 1955; 11(1):68-71. DOI: 10.1111/j.1600-0773.1955.tb00203.x. View

10.

Jones S, Jones M, Basinger M, Burka L, Shinobu L . Polarity and antidotal efficacy of dithiocarbamates in acute cadmium intoxication. Res Commun Chem Pathol Pharmacol. 1983; 40(1):155-64. View

11.

Kahn A, Denis R, Blum D . Accidental ingestion of mercuric sulphate in a 4-year-old child. Management with BAL and peritoneal dialysis. Clin Pediatr (Phila). 1977; 16(10):956-8. DOI: 10.1177/000992287701601015. View

12.

GALE G, Smith A, Walker Jr E . Diethyldithiocarbamate in treatment of acute cadmium poisoning. Ann Clin Lab Sci. 1981; 11(6):476-83. View

13.

Cherian M, Onosaka S, Carson G, Dean P . Biliary excretion of cadmium in rat. V. Effects of structurally related mercaptans on chelation of cadmium from metallothionein. J Toxicol Environ Health. 1982; 9(3):389-99. DOI: 10.1080/15287398209530172. View

14.

Sunderman F . NICKEL AND COPPER MOBILIZATION BY SODIUM DIETHYLDITHIOCARBAMATE. J New Drugs. 1964; 4(3):154-61. DOI: 10.1002/j.1552-4604.1964.tb00196.x. View

15.

ADAM K . The effects of dithiols on the distribution of mercury in rabbits. Br J Pharmacol Chemother. 1951; 6(3):483-91. PMC: 1509136. DOI: 10.1111/j.1476-5381.1951.tb00659.x. View

16.

Cantilena Jr L, Irwin G, Preskorn S, Klaassen C . The effect of diethyldithiocarbamate on brain uptake of cadmium. Toxicol Appl Pharmacol. 1982; 63(3):338-43. DOI: 10.1016/0041-008x(82)90262-9. View

17.

GALE G, Atkins L, Walker Jr E . Effects of diethyldithiocarbamate on organ distribution and excretion of cadmium. Ann Clin Lab Sci. 1982; 12(6):463-70. View

18.

Berlin M, Lewander T . INCREASED BRAIN UPTAKE OF MERCURY CAUSED BY 2,3-DIMERCAPTOPROPANOL (BAL) IN MICE GIVEN MERCURIC CHLORIDE. Acta Pharmacol Toxicol (Copenh). 1965; 22:1-7. DOI: 10.1111/j.1600-0773.1965.tb01805.x. View