Alterations of Phospholipids in Ischemic Canine Myocardium During Acute Arrhythmia

Overview

Journal Lipids

Specialty Biochemistry

Date 1983 Oct 1

PMID 6656533

Citations 12

Authors

R Y Man

T L Slater

M P Pelletier

P C Choy

Affiliations

Soon will be listed here.

Abstract

Myocardial ischemia was produced in the left ventricle of the canine heart by a Harris two-stage occlusion of the left anterior descending coronary artery. The lipid content in the ischemic myocardium was analyzed and compared with the control tissue. No significant change in total phospholipid and cholesterol was detected. A 2-fold elevation in the levels of the major lysophospoholipids was observed during acute ventricular arrhythmias at 24 hr after the onset of ischemia. Such increases were not caused by preferential hydrolysis of phospholipid plasmalogens from the parent phospholipids.

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