Control of Lower-esophageal-sphincter Contractile Activity by Motilin in Conscious Dogs

Overview

Journal Am J Dig Dis

Specialty Gastroenterology

Date 1978 Apr 1

PMID 665630

Citations 2

Authors

Z Itoh

I AIZAWA

R Honda

K Hiwatashi

E F Couch

Affiliations

Soon will be listed here.

Abstract

The effect of synthetic motilin on contractile activity in the lower esophageal sphincter (LES) and the stomach has been studied in 5 healthy dogs by means of chronically implanted strain gage force transducers. Motilin produced strong contractions in the LES and the stomach simultaneously after intravenous doses ranging from 0.3 to 2.7 microgram/kg hr, which were similar to the naturally occurring interdigestive contractions in the LES and the stomach. However, these contractions could be induced only in the interdigestive state; infusion of motilin into dogs in the digestive state brought about no significant effect on either the LES or the stomach. Motilin-induced contractions in the LES and the stomach were instantly abolished by ingestion of food. It is considered that the contractions induced by motilin are identical with the naturally occurring interdigestive contractions in the LES and these contractions are the most orad component of the interdigestive cyclic recurring caudad-moving bands of strong contractions in the dogs.

Citing Articles

The role of motilin and cisapride in the enteric nervous system of the lower esophageal sphincter in humans.

Tomita R, Tanjoh K, Munakata K Surg Today. 1997; 27(11):985-92.

PMID: 9413048 DOI: 10.1007/BF02385776.

Backwards and forwards with the migrating complex.

Wingate D Dig Dis Sci. 1981; 26(7):641-66.

PMID: 7018863 DOI: 10.1007/BF01367678.

References

Domschke W, Lux G, Mitznegg P, Rosch W, Domschke S, Bloom S . Relationship of plasma motilin response to lower esophageal sphincter pressure in man. Scand J Gastroenterol Suppl. 1976; 39:81-4. View

Bass P, WILEY J . Contractile force transducer for recording muscle activity in unanesthetized animals. J Appl Physiol. 1972; 32(4):567-70. DOI: 10.1152/jappl.1972.32.4.567. View

Itoh Z, AIZAWA I, Takeuchi S, Takayanagi R . Diurnal changes in gastric motor activity in conscious dogs. Am J Dig Dis. 1977; 22(2):117-24. DOI: 10.1007/BF01072953. View

Brown J, COOK M, Dryburgh J . Motilin, a gastric motor activity stimulating polypeptide: the complete amino acid sequence. Can J Biochem. 1973; 51(5):533-7. DOI: 10.1139/o73-066. View

Itoh Z, Honda R, Hiwatashi K, Takeuchi S, AIZAWA I, Takayanagi R . Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol Suppl. 1976; 39:93-110. View

Itoh Z, Carlton N, Lucien H, Schally A . Long-term plastic tubing implantation into the external jugular vein for injection or infusion in the dog. Surgery. 1969; 66(4):768-70. View

Jennewein H, Bauer R, Hummelt H, Lepsin G, Siewert R, Waldeck F . Motilin effects on gastrointestinal motility and lower esophageal sphincter (LES) pressure in dogs. Scand J Gastroenterol Suppl. 1976; 39:63-5. View

Brown J, COOK M, Dryburgh J . Motilin, a gastric motor activity-stimulating polypeptide: final purification, amino acid composition, and C-terminal residues. Gastroenterology. 1972; 62(3):401-4. View

Meissner A, Bowes K, Zwick R, Daniel E . Effect of motilin on the lower oesophageal sphincter. Gut. 1976; 17(12):925-32. PMC: 1411234. DOI: 10.1136/gut.17.12.925. View

10.

Eckardt V, Grace N . Lower esophageal sphincter pressure and serum motilin levels. Am J Dig Dis. 1976; 21(12):1008-11. DOI: 10.1007/BF01071855. View

11.

Itoh Z, Honda R, AIZAWA I, Takeuchi S, Hiwatashi K, Couch E . Interdigestive motor activity of the lower esophageal sphincter in the conscious dog. Am J Dig Dis. 1978; 23(3):239-47. DOI: 10.1007/BF01072324. View

12.

Lux G, Rosch W, Domschke S, Domschke W, Wunsch E, Jaeger E . Intravenous 13-Nle-motilin increases the human lower esophageal sphincter pressure. Scand J Gastroenterol Suppl. 1976; 39:75-9. View

13.

Hellemans J, VANTRAPPEN G, Bloom S . Endogenous motilin and the LES pressure. Scand J Gastroenterol Suppl. 1976; 39:67-73. View