Ultrastructural Study of Peripheral Nerve in Arteritic Diabetic Patients

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1983 Jan 1

PMID 6650135

Citations 5

Authors

C Vital

C BRECHENMACHER

J M Serise

R Bellance

A Vital

J F Dartigues

P BOISSIERAS

Affiliations

Soon will be listed here.

Abstract

The peripheral nerve was taken from 25 diabetic patients with arteritis just before or after amputation of a leg. The ultrastructural study of myelinated fibers showed several alterations. Loss of fibers varied greatly from case to case. This was accompanied in some cases by hypertrophy of the Schwann cells around demyelinated fibers as has been observed in some ordinary diabetic neuropathies. Unusual abnormalities consisted of particular axonal degeneration and evidence of aberrant remyelination. This axonal injury was peculiar because of the accumulation of organelles which tended to transform some of the fibers into enlarged axons. Such a lesion might correspond to a hypoxic axonopathy.

Citing Articles

Human cerebral neuropathology of Type 2 diabetes mellitus.

Nelson P, Smith C, Abner E, Schmitt F, Scheff S, Davis G Biochim Biophys Acta. 2008; 1792(5):454-69.

PMID: 18789386 PMC: 2834412. DOI: 10.1016/j.bbadis.2008.08.005.

Axonopathy and microangiopathy in chronic alloxan diabetes.

Powell H, Myers R Acta Neuropathol. 1984; 65(2):128-37.

PMID: 6098120 DOI: 10.1007/BF00690466.

Microangiopathy in human diabetic neuropathy.

Powell H, Rosoff J, Myers R Acta Neuropathol. 1985; 68(4):295-305.

PMID: 4090941 DOI: 10.1007/BF00690832.

Vasculitic neuropathy in panarteritis nodosa: clinical and ultrastructural findings.

Bussone G, La Mantia L, Frediani F, Tredici G, Petruccioli Pizzini M Ital J Neurol Sci. 1986; 7(2):265-9.

PMID: 2873112 DOI: 10.1007/BF02230892.

Polyarteritis nodosa and peripheral neuropathy. Ultrastructural study of 13 cases.

Vital A, Vital C Acta Neuropathol. 1985; 67(1-2):136-41.

PMID: 2862755 DOI: 10.1007/BF00688134.

References

Spencer P . Peripheral nerve abnormalities in aging rats. J Neuropathol Exp Neurol. 1981; 40(2):155-65. DOI: 10.1097/00005072-198103000-00007. View

Ballin R, Thomas P . Hypertrophic changes in diabetic neuropathy. Acta Neuropathol. 1968; 11(2):93-102. DOI: 10.1007/BF00690213. View

Dyck P, LAMBERT E . Polyneuropathy associated with hypothyroidism. J Neuropathol Exp Neurol. 1970; 29(4):631-58. DOI: 10.1097/00005072-197010000-00008. View

LAPRESLE J . [Anatomical study of peripheral neuropathies of diabetes mellitus]. Journ Annu Diabetol Hotel Dieu. 1968; 9:101-13. View

Parry G, Brown M . Selective fiber vulnerability in acute ischemic neuropathy. Ann Neurol. 1982; 11(2):147-54. DOI: 10.1002/ana.410110207. View

Eames R, Lange L . Clinical and pathological study of ischaemic neuropathy. J Neurol Neurosurg Psychiatry. 1967; 30(3):215-26. PMC: 496172. DOI: 10.1136/jnnp.30.3.215. View

Asbury A, Gale M, Cox S, Baringer J, Berg B . Giant axonal neuropathy--a unique case with segmental neurofilamentous masses. Acta Neuropathol. 1972; 20(3):237-47. DOI: 10.1007/BF00686905. View

Behse F, BUCHTHAL F, Carlsen F . Nerve biopsy and conduction studies in diabetic neuropathy. J Neurol Neurosurg Psychiatry. 1977; 40(11):1072-82. PMC: 492905. DOI: 10.1136/jnnp.40.11.1072. View

Clements Jr R . Diabetic neuropathy--new concepts of its etiology. Diabetes. 1979; 28(6):604-11. DOI: 10.2337/diab.28.6.604. View

10.

Bischoff A . [DIABETIC NEUROPATHIES]. Praxis. 1965; 54:723-9. View

11.

Korthals J, Korthals M, Wisniewski H . Peripheral nerve ischemia: Part 2. Accumulation of organelles. Ann Neurol. 1978; 4(6):487-98. DOI: 10.1002/ana.410040603. View

12.

Raff M, Asbury A . Ischemic mononeuropathy and mononeuropathy multiplex in diabetes mellitus. N Engl J Med. 1968; 279(1):17-21. DOI: 10.1056/NEJM196807042790104. View

13.

Schaumburg H, Wisniewski H, Spencer P . Ultrastructural studies of the dying-back process. I. Peripheral nerve terminal and axon degeneration in systemic acrylamide intoxication. J Neuropathol Exp Neurol. 1974; 33(2):260-84. DOI: 10.1097/00005072-197404000-00006. View

14.

Sugimura K, Dyck P . Sural nerve myelin thickness and axis cylinder caliber in human diabetes. Neurology. 1981; 31(9):1087-91. DOI: 10.1212/wnl.31.9.1087. View

15.

Dyck P, Johnson W, LAMBERT E, OBrien P . Segmental demyelination secondary to axonal degeneration in uremic neuropathy. Mayo Clin Proc. 1971; 46(6):400-31. View

16.

CASTAIGNE P, CATHALA H, Dry J, MASTROPAOLO C . [The responses of the nerves and muscles to electric stimulations during a tourniquet ischemia test in normal and diabetic subjects]. Rev Neurol (Paris). 1966; 115(1):61-6. View

17.

Vital C, Vallat J, Le Blanc M, Martin F, Coquet M . [Peripheral neuropathies caused by diabetes mellitus. Ultrastructural study of 12 biopsied cases]. J Neurol Sci. 1973; 18(4):381-98. DOI: 10.1016/0022-510x(73)90133-0. View

18.

Dyck P, Conn D, Okazaki H . Necrotizing angiopathic neuropathy. Three-dimensional morphology of fiber degeneration related to sites of occluded vessels. Mayo Clin Proc. 1972; 47(7):461-75. View

19.

Vital C, Le Blanc M, Vallat J, Cocquet M, Vallat M, ROQUES J . [Ultrastructural study of pheripheral nerve in 16 diabetics without neuropathy. Comparisons with 16 diabetic neuropathies and 16 non-diabetic neuropathies (author's transl)]. Acta Neuropathol. 1974; 30(1):63-72. DOI: 10.1007/BF00685323. View

20.

Tohgi H, Tsukagoshi H, TOYOKURA Y . Quantitative changes with age in normal sural nerves. Acta Neuropathol. 1977; 38(3):213-20. DOI: 10.1007/BF00688067. View