Improved Diagnosis of Mastocytosis by Measurement of Urinary Histamine Metabolites

Overview

Journal N Engl J Med

Specialty General Medicine

Date 1983 Dec 29

PMID 6646186

Citations 27

Authors

J J Keyzer

J G de Monchy

J J van Doormaal

P C van Voorst Vader

Affiliations

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Abstract

In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of histamine, whereas only three had above-normal values for histamine. In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the diagnosis of mastocytosis than the determination of histamine itself.

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