Experimental Allergic Neuritis-like Disease in Rabbits After Injection with Influenza Vaccines Mixed with Gangliosides and Adjuvants

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1983 Nov 1

PMID 6642653

Citations 3

Authors

D W ZIEGLER

J J Gardner

D T Warfield

H H Walls

Affiliations

Soon will be listed here.

Abstract

An experimental allergic neuritis-like disease was induced in rabbits 3 to 8 weeks after injection with large doses of influenza vaccines mixed with gangliosides, cholesterol, and Freund complete adjuvant. The inclusion of gangliosides was essential to induce the experimental allergic neuritis-like disease. In trials with six different lots of vaccine, both swine influenza and non-swine influenza vaccines produced by four different manufacturers induced experimental allergic neuritis-like disease in 26 of 43 inoculated rabbits.

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