Effects of Cyclosporin A on Mouse Lymphoid Tissues

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1983 Oct 1

PMID 6639872

Authors

O Kai

R M Franklin

Affiliations

Soon will be listed here.

Abstract

Cyclosporin A (CsA) was administered s.c. to BALB/c and C3H mice for periods up to 25 days and the effects were monitored by the immune response to SRBC, HGG, and B. abortus. Whereas the rate of growth of BALB/c mice was only depressed after the 20th day, C3H mice lost weight from the start of treatment. In both strains there was no change in the weight of the spleen and mesenteric lymph node but the thymus weight decreased markedly. This decrease in thymus weight was accompanied by thymic involution with little or no change in spleen or mesenteric lymph node. An increase in Mott cells, as so strikingly demonstrated in the CsA-treated chicken (Nowak et al., 1982), was dependent on the degree of thymic involution. When the thymus was normal in appearance there was a slight increase in the number of splenic Mott cells, when compared with untreated controls; in the more usual case of thymic involution (or necrosis), there was no increase in the number of Mott cells.

References

TOIVANEN P, Toivanen A . Bursal and postbursal stem cells in chicken. Functional characteristics. Eur J Immunol. 1973; 3(9):585-95. DOI: 10.1002/eji.1830030912. View

Weber K, Bibring T, Osborn M . Specific visualization of tubulin-containing structures in tissue culture cells by immunofluorescence. Cytoplasmic microtubules, vinblastine-induced paracrystals, and mitotic figures. Exp Cell Res. 1975; 95(1):111-20. DOI: 10.1016/0014-4827(75)90615-1. View

White D, Calne R, Plumb A . Mode of action of cyclosporin A: a new immunosuppressive agent. Transplant Proc. 1979; 11(1):855-9. View

Kunkl A, Klaus G . Selective effects of cyclosporin A on functional B cell subsets in the mouse. J Immunol. 1980; 125(6):2526-31. View

Baldwin 3rd W, Hutchinson I, Meijer C, Tilney N . Immune responses to organ allografts. III. Marked decrease in medullary thymocytes and splenic T lymphocytes after cyclosporin A treatment. Transplantation. 1981; 31(2):117-20. View

Green C . Immunosuppression with cyclosporin A: a review. Diagn Histopathol. 1981; 4(2):157-74. View

Dongworth D, Klaus G . Effects of cyclosporin A on the immune system of the mouse. I. Evidence for a direct selective effect of cyclosporin A on B cells responding to anti-immunoglobulin antibodies. Eur J Immunol. 1982; 12(12):1018-22. DOI: 10.1002/eji.1830121207. View

Ryffel B, Deyssenroth H, Borel J . Cyclosporin A: effects on the mouse thymus. Agents Actions. 1981; 11(4):373-9. DOI: 10.1007/BF01982473. View

Smith G . The effect of cyclosporin A on the primary immune response to allogeneic red cells in rabbits. Immunology. 1982; 45(1):163-7. PMC: 1555166. View

10.

Whiting P, Thomson A, Blair J, Simpson J . Experimental cyclosporin A nephrotoxicity. Br J Exp Pathol. 1982; 63(1):88-94. PMC: 2040750. View

11.

Blair J, Thomson A, Whiting P, Davidson R, Simpson J . Toxicity of the immune suppressant cyclosporin A in the rat. J Pathol. 1982; 138(2):163-78. DOI: 10.1002/path.1711380206. View

12.

Nowak J, Kai O, Peck R, Franklin R . The effects of cyclosporin A on the chicken immune system. Eur J Immunol. 1982; 12(10):867-76. DOI: 10.1002/eji.1830121013. View

13.

Paavonen T, Jarvelainen H, Kontiainen S, Hayry P . Effect of cyclosporin A on in vitro proliferative activity and immunoglobulin synthesis of isolated human lymphoid cell subpopulations. Clin Exp Immunol. 1981; 43(2):342-50. PMC: 1537293. View