Nitrite and Nitrate Are Formed by Endogenous Synthesis in the Human Intestine

Overview

Journal Science

Specialty Science

Date 1978 Jun 30

PMID 663630

Citations 41

Authors

S R Tannenbaum

D Fett

V R Young

P D Land

W R Bruce

Affiliations

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Abstract

Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.

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