Des-Tyr1-gamma-endorphin and Haloperidol Increase Pineal Gland Melatonin Levels in Rats
Overview
Authors
Affiliations
The effect of subcutaneously injected DT gamma E (beta-endorphin, (beta E)2-17) on the pineal melatonin level was compared with that of closely related peptides and the neuroleptic drug haloperidol. As found previously, DT gamma E (3 ng/rat and 300 ng/rat) increased the melatonin levels. Similar doses of DT alpha E (beta E 2-16), DT beta E (beta E 2-31), gamma E (beta E 1-17), alpha E (beta E 1-16) and beta E failed to significantly change the melatonin levels in both the dark and the light phase. Haloperidol in a dose of 300 ng/rat exhibited a similar effect as DT gamma E.
Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism.
Vaiman E, Shnayder N, Khasanova A, Strelnik A, Gayduk A, Al-Zamil M Biomedicines. 2022; 10(8).
PMID: 36009557 PMC: 9405702. DOI: 10.3390/biomedicines10082010.
Mittal V, Karlsgodt K, Zinberg J, Cannon T, Bearden C Am J Psychiatry. 2010; 167(9):1033-7.
PMID: 20826854 PMC: 4414088. DOI: 10.1176/appi.ajp.2010.09071043.
Melatonin and gonadotropin secretion after acute exercise in physically active males.
Elias A, Wilson A, Pandian M, Rojas F, Kayaleh R, Stone S Eur J Appl Physiol Occup Physiol. 1993; 66(4):357-61.
PMID: 8495699 DOI: 10.1007/BF00237782.
Esposti D, Lissoni P, Mauri R, ROVELLI F, Orsenigo L, Pescia S J Endocrinol Invest. 1988; 11(2):103-6.
PMID: 3361078 DOI: 10.1007/BF03350114.
A clinical study on the relationship between the pineal gland and the opioid system.
Lissoni P, Esposti D, Esposti G, Mauri R, Resentini M, Morabito F J Neural Transm. 1986; 65(1):63-73.
PMID: 2937880 DOI: 10.1007/BF01249612.