Oesophageal Mucosal Changes in Patients with Varices

Overview

Journal Gut

Specialty Gastroenterology

Date 1983 Nov 1

PMID 6629111

Citations 8

Authors

R A Spence

J M Sloan

G W JOHNSTON

A Greenfield

Affiliations

Soon will be listed here.

Abstract

Histological examination of oesophageal rings removed at transection for varices reveals dilated intraepithelial blood filled channels. These are present in all oesophageal rings removed at transection for varices. A comparison has been made between rings removed from variceal patients with oesophageal rings removed during resections for oesophageal and gastric tumours. Although a small number of non-varices patients had intraepithelial channels they were significantly larger and more numerous in the varices patients (p less than 0.01). Similarly, the area and number of dilated subepithelial channels (just beneath the epithelium) and the area of lamina propria channels were significantly greater in the varices patients (p less than 0.05). Depth of papillae and thickness of the squamous epithelium were also significantly greater in the varices group (p less than 0.05, p less than 0.01 respectively). Under electron microscopy the channels were lined with flattened cells which were not typical of endothelial cells but stained positively for Factor VIII related antigen using indirect immunofluorescence. These channels may correspond to the cherry-red spots seen on endoscopy and may have a role in the pathogenesis of variceal haemorrhage.

Citing Articles

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Serum-ascites albumin gradient: a predictor of esophageal varices with ascites.

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Portal hypertensive gastric mucosa: an endoscopic study.

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Why have controlled trials failed to demonstrate a benefit of esophagogastroduodenoscopy in acute upper gastrointestinal bleeding? A probability model analysis.

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