The Influence of Uremia on the Accessibility of Phosphomycin into Interstitial Tissue Fluid

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1983 Jan 1

PMID 6628521

Citations 7

Authors

C Fernandez Lastra

E L Marino

A Dominguez-Gil

J M Tabernero

A Gonzalez Lopez

M Yuste Chaves

Affiliations

Soon will be listed here.

Abstract

The entry and persistence of phosphomycin in interstitial tissue fluid (ITF) were studied in 9 patients with normal renal function and 8 patients with varying degrees of renal impairment, all of whom received a single i.v. dose of 30 mg/kg. ITF was obtained from skin blisters produced by suction. The antibiotic followed a two-compartment open kinetic model. In patients with normal renal function, phosphomycin is incorporated rapidly into the ITF reaching a level of 60.4 micrograms/ml 60 min after administration. There was no statistically significant difference between the elimination rates from serum and ITF. The serum half-life of the slow disposition phase was 1.75 h in patients with normal renal function. There was a linear correlation between the elimination half-life of phosphomycin in serum and ITF in subjects with differing degrees of renal impairment.

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References

Meyers B, Ribner B, Yancovitz S, Hirschman S . Pharmacological studies with cefamandole in human volunteers. Antimicrob Agents Chemother. 1976; 9(1):140-4. PMC: 429489. DOI: 10.1128/AAC.9.1.140. View

Klotz U . Pathophysiological and disease-induced changes in drug distribution volume: pharmacokinetic implications. Clin Pharmacokinet. 1976; 1(3):204-18. DOI: 10.2165/00003088-197601030-00003. View

Madhavan T, Yaremchuk K, Levin N, Pohlod D, Burch K, Fisher E . Effect of renal failure and dialysis on the serum concentration of the aminoglycoside amikacin. Antimicrob Agents Chemother. 1976; 10(3):464-6. PMC: 429772. DOI: 10.1128/AAC.10.3.464. View

FOLTZ E, WALLICK H . Pharmacodynamics of phosphonomycin after intravenous administration in man. Antimicrob Agents Chemother (Bethesda). 1969; 9:316-21. View

Ng P . Determining aminoglycoside dosage and blood levels using a programmable calculator. Am J Hosp Pharm. 1980; 37(2):225-31. View

FOSTER T, Bourne D . Use of a programmable hand-held calculator for clinical pharmacokinetics. Am J Hosp Pharm. 1977; 34(1):70-5. View

Kestle D, KIRBY W . Clinical pharmacology and in vitro activity of phosphonomycin. Antimicrob Agents Chemother (Bethesda). 1969; 9:332-7. View

Ritschel W, Banarer M, Diaz D, Margary J, Otero J . Analog computer monitoring and evaluation of a dosing nomogram for gentamicin based on the c'min-method: Part I. Int J Clin Pharmacol Ther Toxicol. 1980; 18(10):425-30. View

CADORNIGA R, Diaz Fierros M, Olay T . Pharmacokinetic study of fosfomycin and its bioavailability. Chemotherapy. 1977; 23 Suppl 1:159-74. DOI: 10.1159/000222043. View

10.

Garcia M, Dominguez-Gil A, Tabernero J, Sanchez Tomero J . Pharmacokinetics of cefoxitin in patients with normal or impaired renal function. Eur J Clin Pharmacol. 1979; 16(2):119-24. DOI: 10.1007/BF00563118. View

11.

Kiistala U, MUSTAKALLIO K . Dermo-epidermal separation with suction. Electron microscopic and histochemical study of initial events of blistering on human skin. J Invest Dermatol. 1967; 48(5):466-77. View

12.

Reidenberg M, Drayer D . Effects of renal disease upon drug disposition. Drug Metab Rev. 1978; 8(2):293-302. DOI: 10.3109/03602537808993789. View

13.

Benet L . General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. J Pharm Sci. 1972; 61(4):536-41. DOI: 10.1002/jps.2600610408. View

14.

Kwan K, WADKE D, FOLTZ E . Pharmacokinetics of phosphonomycin in Man. I. Intravenous administration. J Pharm Sci. 1971; 60(5):678-85. DOI: 10.1002/jps.2600600504. View

15.

Gram L . Plasma level monitoring of tricyclic antidepressant therapy. Clin Pharmacokinet. 1977; 2(4):237-51. DOI: 10.2165/00003088-197702040-00001. View

16.

IISALO E . Clinical pharmacokinetics of digoxin. Clin Pharmacokinet. 1977; 2(1):1-16. DOI: 10.2165/00003088-197702010-00001. View

17.

FARAGO E, Kiss I, MIHOCZY L . Data on sisomicin effect: human pharmacokinetic and bacteriological studies. Int J Clin Pharmacol Ther Toxicol. 1980; 18(3):128-32. View

18.

Vicente M, Olay T, Quecedo M, Rodriguez A . Diffusion of beta-lactam antibiotics and fosfomycin to interstitial tissue fluid in rabbits. Chemotherapy. 1979; 25(6):329-35. DOI: 10.1159/000237860. View

19.

Levy G, Gibaldi M, Jusko W . Multicompartment pharmacokinetic models and pharmacologic effects. J Pharm Sci. 1969; 58(4):422-4. DOI: 10.1002/jps.2600580406. View

20.

Garcia M, Cepeda M, Lanao J, Dominguez-Gil A . Influence of acute renal impairment in the penetration of cefoxitin into interstitial tissue fluid in rabbits. Clin Ther. 1981; 3(6):413-24. View