Bombesin-like Immunoreactivity in the Pituitary Gland

Overview

Journal Experientia

Specialty Science

Date 1983 Oct 15

PMID 6617818

Citations 1

Authors

J Major

M A Ghatei

S R Bloom

Affiliations

Soon will be listed here.

Abstract

Bombesin has been shown to stimulate release of anterior pituitary hormones both in vivo and in vitro. The aim of this study was to determine whether bombesin-like immunoreactivity could be detected in the human pituitary. Significant concentrations were found in the human anterior gland (4.6 +/- 1.5 pmoles/g), posterior gland (1.5 +/- 0.4 pmoles/g) and stalk (8.1 +/- 0.8 pmoles/g). Significant amounts were also observed in the guinea-pig pituitary. Gel permeation chromatography revealed the presence of 2 major molecular forms of bombesin-like immunoreactivity, one co-eluting with porcine gastrin-releasing peptide and the other with amphibian bombesin.

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