Tumor Heterogeneity: Biological Implications and Therapeutic Consequences

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 1983 Jan 1

PMID 6616442

Citations 115

Authors

G H Heppner

B E Miller

Affiliations

Soon will be listed here.

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References

Mantovani A, Giavazzi R, Alessandri G, Spreafico F, Garattini S . Characterization of tumor lines derived from spontaneous metastases of a transplanted murine sarcoma. Eur J Cancer (1965). 1981; 17(1):71-6. DOI: 10.1016/0014-2964(81)90213-9. View

Fuji H, Mihich E, Pressman D . Differential tumor immunogenicity of L1210 and its sublines. I. Effect of an increased antigen density on tumor cell surfaces on primary B cell responses in vitro. J Immunol. 1977; 119(3):983-6. View

Poste G, Nicolson G . Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells. Proc Natl Acad Sci U S A. 1980; 77(1):399-403. PMC: 348278. DOI: 10.1073/pnas.77.1.399. View

Rubin H . Is somatic mutation the major mechanism of malignant transformation?. J Natl Cancer Inst. 1980; 64(5):995-1000. View

DULBECCO R, Henahan M, Bowman M, Okada S, Battifora H, Unger M . Generation of fibroblast-like cells from cloned epithelial mammary cells in vitro: a possible new cell type. Proc Natl Acad Sci U S A. 1981; 78(4):2345-9. PMC: 319342. DOI: 10.1073/pnas.78.4.2345. View

SOULE H, Maloney T, McGrath C . Phenotypic variance among cells isolated from spontaneous mouse mammary tumors in primary suspension culture. Cancer Res. 1981; 41(3):1154-64. View

BROWNING H . Heterologous and homologous growth of transplants during the course of development of spontaneous mammary tumors in C3H mice. J Natl Cancer Inst. 1948; 8(4):173-89. View

Miller B, Miller F, Heppner G . Interactions between tumor subpopulations affecting their sensitivity to the antineoplastic agents cyclophosphamide and methotrexate. Cancer Res. 1981; 41(11 Pt 1):4378-81. View

Weiss M, Michael J, Pesce A, DiPersio L . Heterogeneity of beta 2-microglobulin in human breast carcinoma. Lab Invest. 1981; 45(1):46-57. View

10.

Weitzman S, Stossel T . Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis. J Immunol. 1982; 128(6):2770-2. View

11.

Becker F, Klein K, WOLMAN S, Asofsky R, Sell S . Characterization of primary hepatocellular carcinomas and initial transplant generations. Cancer Res. 1973; 33(12):3330-8. View

12.

Tan M, Shimano T, Chu T . Differential localization of human pancreas cancer-associated antigen and carcinoembryonic antigen in homologous pancreatic tumoral xenograft. J Natl Cancer Inst. 1981; 67(3):563-9. View

13.

Baylin S, Weisburger W, Eggleston J, Mendelsohn G, BEAVEN M, Abeloff M . Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications. N Engl J Med. 1978; 299(3):105-10. DOI: 10.1056/NEJM197807202990301. View

14.

McDowell E, Sorokin S, Hoyt Jr R, Trump B . An unusual bronchial carcinoid tumor: light and electron microscopy. Hum Pathol. 1981; 12(4):338-48. DOI: 10.1016/s0046-8177(81)80143-8. View

15.

Berranco S, Drewinko B, HUMPHREY R . Differential response by human melanoma cells to 1,3-bis-(2-chloroethyl)-1-nitrosourea and bleomycin. Mutat Res. 1973; 19(2):277-80. DOI: 10.1016/0027-5107(73)90089-4. View

16.

ISHIDATE Jr M, Aoshima M, Sakurai Y . Population changes of a rat leukemia by different routes of transplantation. J Natl Cancer Inst. 1974; 53(3):773-81. DOI: 10.1093/jnci/53.3.773. View

17.

Hager J, Heppner G . Heterogeneity of expression and induction of mouse mammary tumor virus antigens in mouse mammary tumors. Cancer Res. 1982; 42(11):4325-9. View

18.

Hakansson L, Trope C . Cell clones with different sensitivity to cytostatic drugs in methylcholanthrene-induced mouse sarcomas. Acta Pathol Microbiol Scand A. 1974; 82(1):41-7. DOI: 10.1111/j.1699-0463.1974.tb03826.x. View

19.

Varani J, Orr W, Ward P . A comparison of the migration patterns of normal and malignant cells in two assay systems. Am J Pathol. 1978; 90(1):159-72. PMC: 2018218. View

20.

Aubert C, Rouge F, Galindo J . Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro. J Natl Cancer Inst. 1980; 64(5):1029-40. View