Zinc Ion Binding to Human Brain Calcium Binding Proteins, Calmodulin and S100b Protein

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1983 Aug 12

PMID 6615509

Citations 24

Authors

J Baudier

K Haglid

J Haiech

D Gerard

Affiliations

Soon will be listed here.

Abstract

Comparative studies have been performed on the binding properties of zinc ions to human brain calmodulin and S100b protein. Calmodulin is characterized by two sets of Zn2+ binding sites, with KD ranging from 8.10(-5)M to 3.10(-4)M. The S100b protein also exhibited two sets of zinc binding sites, with a much higher affinity. KD = 10(-7) - 10(-6)M. We suggest that S100b protein should no longer be considered only as a "calcium binding protein" but also as a "zinc binding protein", and that Zn2+ ions are involved in the functions of the S100 proteins.

Citing Articles

Calcium's Role and Signaling in Aging Muscle, Cellular Senescence, and Mineral Interactions.

Terrell K, Choi S, Choi S Int J Mol Sci. 2023; 24(23).

PMID: 38069357 PMC: 10706910. DOI: 10.3390/ijms242317034.

The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart.

Dorward A, Stewart A, Pitt S J Gen Physiol. 2023; 155(7).

PMID: 37326614 PMC: 10276528. DOI: 10.1085/jgp.202213206.

Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3.

Shih P, Fang Y, Shankar S, Lee S, Hu H, Chen H Nat Commun. 2022; 13(1):2664.

PMID: 35562389 PMC: 9106668. DOI: 10.1038/s41467-022-30353-0.

Zinc: Multidimensional Effects on Living Organisms.

Cuajungco M, Ramirez M, Tolmasky M Biomedicines. 2021; 9(2).

PMID: 33671781 PMC: 7926802. DOI: 10.3390/biomedicines9020208.

Zinc Increases ABCA1 by Attenuating Its Clearance Through the Modulation of Calmodulin Activity.

Lu R, Ishikawa T, Tanaka M, Tsuboi T, Yokoyama S J Atheroscler Thromb. 2020; 28(3):261-270.

PMID: 32581187 PMC: 8049148. DOI: 10.5551/jat.55384.