Thymic T Cells Are Driven to Expand Upon Interaction with Self-class II Major Histocompatibility Complex Gene Products on Accessory Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 Feb 1

PMID 6608107

Citations 10

Authors

K L Rock

B Benacerraf

Affiliations

Soon will be listed here.

Abstract

Murine thymocytes induce the monokine interleukin 1 upon in vitro coculture with a radioresistant Ia-bearing accessory cell [murine Ia molecule is a class II major histocompatibility complex (MHC) antigen]. The generation of interleukin 1 is critically dependent on the function of I-region gene products on accessory cells. The induced interleukin 1 appears to allow the activation and proliferation of self-MHC-specific thymocytes. Thus, in the absence of added exogenous factors, there is an Ia-dependent thymocyte proliferation. This selective activation of thymocytes is observed with both mature and immature thymic T cells. This in vitro response results in the selective amplification of developing T cells with self-MHC specificity and could be of importance to the in vivo commitment of T cells to MHC determinants that occurs in the thymus.

Citing Articles

Analysis of thymocyte MHC specificity with thymocyte hybridomas.

Yeh E, Benacerraf B, Rock K J Exp Med. 1984; 160(3):799-813.

PMID: 6206189 PMC: 2187409. DOI: 10.1084/jem.160.3.799.

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.

Kruisbeek A, Mond J, Fowlkes B, Carmen J, Bridges S, Longo D J Exp Med. 1985; 161(5):1029-47.

PMID: 3921649 PMC: 2187596. DOI: 10.1084/jem.161.5.1029.

Acquisition of MHC-restriction specificities: role of thymic stromal cells.

Kruisbeek A, Longo D Surv Immunol Res. 1985; 4(2):110-9.

PMID: 3898273 DOI: 10.1007/BF02918807.

Monoclonal antibodies against human Ia antigens stimulate monocytes to secrete interleukin 1.

Palacios R Proc Natl Acad Sci U S A. 1985; 82(19):6652-6.

PMID: 3876560 PMC: 391268. DOI: 10.1073/pnas.82.19.6652.

In vitro effects of gold sodium thiomalate on IL-1, IL-2 production, IL-2 receptor expression and IL-2 responsiveness in thymocytes and peripheral blood mononuclear cells.

Streller A Clin Exp Immunol. 1987; 68(2):357-65.

PMID: 3115645 PMC: 1542720.

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