Phenotypic Characterization of Synovial Tissue Cells in Situ in Different Types of Synovitis

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1983 Nov 1

PMID 6605750

Citations 37

Authors

S Lindblad

L Klareskog

E Hedfors

U Forsum

C Sundstrom

Affiliations

Soon will be listed here.

Abstract

Immunohistochemical double-staining was performed on frozen sections from synovial biopsies obtained at arthroscopy from 22 patients with different kinds of synovitis. Not only in specimens from patients with rheumatoid arthritis and seronegative chronic polyarthritis, but also in those from patients with synovitis due to psoriasis, trauma, or crystals, were seen many alpha Leu-1-positive T lymphocytes--in most cases predominantly of the alpha Leu-3a-positive T "helper" cell type--in close contact with HLA-DR-positive macrophages/dendritic cells. Presence of many HLA-DR-positive, often OKM1-negative, and irregular sublining cells characterized all forms of chronic arthritis.

Citing Articles

Antibody-based targeted delivery of interleukin-4 synergizes with dexamethasone for the reduction of inflammation in arthritis.

Schmid A, Hemmerle T, Pretto F, Kipar A, Neri D Rheumatology (Oxford). 2018; 57(4):748-755.

PMID: 29365185 PMC: 6104808. DOI: 10.1093/rheumatology/kex447.

The onset of rheumatoid arthritis following trauma.

Brawer A, Goel N Open Access Rheumatol. 2016; 8:77-80.

PMID: 27843373 PMC: 5098718. DOI: 10.2147/OARRR.S110560.

[Synovial biomarkers for differential diagnosis of painful arthroplasty].

Banke I, Stade N, Prodinger P, Muhlhofer H, Thomas P, Thomas B Orthopade. 2015; 44(12):93, 936-8, 940-1.

PMID: 26542406 DOI: 10.1007/s00132-015-3188-7.

Neutrophils: the forgotten cell in JIA disease pathogenesis.

Jarvis J, Jiang K, Petty H, Centola M Pediatr Rheumatol Online J. 2007; 5:13.

PMID: 17567896 PMC: 1904449. DOI: 10.1186/1546-0096-5-13.

The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).

Kraan M, Patel D, Haringman J, Smith M, Weedon H, Ahern M Arthritis Res. 2001; 3(1):65-71.

PMID: 11178128 PMC: 17826. DOI: 10.1186/ar141.