Immunologic Status in Infants and Children Following Surgery

Overview

Journal Infection

Date 1983 Mar 1

PMID 6602772

Citations 1

Authors

R Kurz

K P Pfeiffer

H Sauer

Affiliations

Soon will be listed here.

Abstract

The investigation of cellular and humoral immunologic parameters (T and B lymphocytes and immunoglobulins) with respect to postoperative infection in children revealed changes in the T lymphocytes in particular. Preoperative complications (ileus, shock, infection), anesthesia and surgery lead to transient immunosuppression. The duration of this T cell suppression is age-dependent; suppression is longest in newborns (up to three weeks on the average) and shortest in older children (one week on the average). IgA and IgG concentrations show only slight abnormal changes; IgM concentrations, however, increase significantly during the postoperative period in all age groups. Prophylactic and therapeutic measures for the prevention of postoperative infections can be considered on the basis of immunologic changes related to surgery.

Citing Articles

[Pathogenesis and therapy of ileus in childhood].

Sauer H Langenbecks Arch Chir. 1985; 366:303-11.

PMID: 4058169 DOI: 10.1007/BF01836652.

References

Lee Y . Effect of anesthesia and surgery on immunity. J Surg Oncol. 1977; 9(5):425-30. DOI: 10.1002/jso.2930090503. View

Fleisher T, Luckasen J, Sabad A, Gehrtz R, Kersey J . T and B lymphocyte subpopulations in children. Pediatrics. 1975; 55(2):162-5. View

JOHANSSON S, Berg T . Immunoglobulin levels in healthy children. Acta Paediatr Scand. 1967; 56(6):572-9. DOI: 10.1111/j.1651-2227.1967.tb15982.x. View

Michlmayr G, Pathouli C, Falkensammer M, Huber C, HUBER H, BRAUNSTEINER H . [Rosette tests in lymphoproliferative diseases]. Schweiz Med Wochenschr. 1976; 106(23):794-9. View

Maclean L, Meakins J, Taguchi K, Duignan J, Dhillon K, Gordon J . Host resistance in sepsis and trauma. Ann Surg. 1975; 182(3):207-17. PMC: 1343926. DOI: 10.1097/00000658-197509000-00004. View

Jubert A, Lee E, Hersh E, McBride C . Effects of surgery, anesthesia and intraoperative blood loss on immunocompetence. J Surg Res. 1973; 15(6):399-403. DOI: 10.1016/0022-4804(73)90110-8. View

Duchateau J, Delespesse G, Vereecke P . Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects. Am J Clin Nutr. 1981; 34(1):88-93. DOI: 10.1093/ajcn/34.1.88. View

Stiehm E, Fudenberg H . Serum levels of immune globulins in health and disease: a survey. Pediatrics. 1966; 37(5):715-27. View

Jondal M . SRBC rosette formation as a human T lymphocyte marker. Scand J Immunol. 1976; Suppl 5:69-76. DOI: 10.1111/j.1365-3083.1976.tb03857.x. View

10.

RIDDLE P, BERENBAUM M . Postoperative depression of the lymphocyte response to phytohaemagglutinin. Lancet. 1967; 1(7493):746-8. DOI: 10.1016/s0140-6736(67)91364-5. View

11.

Belohradsky B, Simon G, SPIER J, Roos R, Marget W . The immunological state of the neonate following surgery--consequences for immunotherapy of neonatal septicaemia. Prog Pediatr Surg. 1979; 13:39-50. View

12.

Fuller J, KEYSER J . Serum immunoglobulins after surgical operation. Clin Chem. 1975; 21(6):667-71. View

13.

Koenig A, Koenig U, Stoeckel H . [Anaesthesia and immunology (author's transl)]. Prakt Anaesth. 1978; 13(5):415-29. View

14.

Cohnen G . Changes in immunoglobulin levels after surgical trauma. J Trauma. 1972; 12(3):249-53. DOI: 10.1097/00005373-197203000-00009. View

15.

Lundy J, Lovett 3rd E, Hamilton S, Conran P . Halothane, surgery, immunosuppression and artificial pulmonary metastases. Cancer. 1978; 41(3):827-30. DOI: 10.1002/1097-0142(197803)41:3<827::aid-cncr2820410307>3.0.co;2-#. View

16.

Mancini G, Carbonara A, Heremans J . Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965; 2(3):235-54. DOI: 10.1016/0019-2791(65)90004-2. View

17.

Bhaskaram C, Raghuramulu N, Reddy V . Cell-mediated immunity and immunoglobulin levels in light-for-date infants. Acta Paediatr Scand. 1977; 66(5):617-9. DOI: 10.1111/j.1651-2227.1977.tb07957.x. View

18.

Puri P, Reen D, Browne O, Blake P, Guiney E . Lymphocyte response after surgery in the neonate. Arch Dis Child. 1979; 54(8):599-603. PMC: 1545773. DOI: 10.1136/adc.54.8.599. View

19.

WINGARD D, Lang R, HUMPHREY L . Effect of anesthesia on immunity. J Surg Res. 1967; 7(9):430-2. DOI: 10.1016/0022-4804(67)90089-3. View

20.

Pietsch J, Meakins J . Predicting infection in surgical patients. Surg Clin North Am. 1979; 59(2):185-97. DOI: 10.1016/s0039-6109(16)41779-2. View