Biological Effects of Trilostane in Vitro on Oocyte Maturation and Fertilization in the Hamster

Overview

Journal Experientia

Specialty Science

Date 1984 Nov 15

PMID 6594245

Citations 2

Authors

S Suzuki

Y Endo

R Miura

R Iizuka

Affiliations

Soon will be listed here.

Abstract

The effects of the inhibition of steroidogenesis by trilostane on oocyte maturation were examined by studying spontaneous maturation and fertilization in vitro. 10(-6)M trilostane had no influence on the meiotic process, whether the oocytes were naked or not. At a concentration of 10(-6)M and 10(-7)M trilostane, low normal pronuclear formation and high polyspermy were found during in vitro fertilization. However, no retarded male pronuclear development could be detected in the trilostane-treated group. Thus, steroid producing activity within ova is apparently necessary to prevent multiple sperm penetration, but it has no effect on meiosis or the action of the so-called male pronucleus growth factor (MPGF).

Citing Articles

Midcycle administration of a progesterone synthesis inhibitor prevents ovulation in primates.

Hibbert M, Stouffer R, Wolf D, Zelinski-Wooten M Proc Natl Acad Sci U S A. 1996; 93(5):1897-901.

PMID: 8700855 PMC: 39879. DOI: 10.1073/pnas.93.5.1897.

Cooperative inhibitory effect of follicular fluid and cAMP on hamster oocyte maturation.

Suzuki S, Kurasawa S, Kitai H, Oba M, Komatsu S, Yoda K Experientia. 1986; 42(7):795-8.

PMID: 3015667 DOI: 10.1007/BF01941527.

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