An HLA-All Association with the Hemochromatosis Allele?

Overview

Journal Clin Genet

Specialty Genetics

Date 1983 Sep 1

PMID 6578890

Citations 7

Authors

L Le Mignon

M Simon

R Fauchet

G Edan

M Le Reun

P Brissot

B GENETET

M BOUREL

Affiliations

Soon will be listed here.

Abstract

Two hundred and seventy-four patients with hemochromatosis and 1005 controls were HLA-typed, and HLA haplotypes were determined for 163 patients and 123 controls. The increased frequency of antigen A3 and haplotypes A3, B7 and A3, B14 in patients with hemochromatosis was confirmed. After correction for the space taken up by A3, a significant increase in All was found. This increase could not be explained by cross reaction between A3 and All. All showed a phenotype association and a haplotype link with Bw35. The genetic significance of this increased All frequency is discussed.

Citing Articles

Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.

Lalouel J, Le Mignon L, Simon M, Fauchet R, BOUREL M, Rao D Am J Hum Genet. 1985; 37(4):700-18.

PMID: 9556659 PMC: 1684619.

Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE).

Yaouanq J, Perichon M, Chorney M, Pontarotti P, LE TREUT A, El Kahloun A Am J Hum Genet. 1994; 54(2):252-63.

PMID: 8304342 PMC: 1918150.

Non-HLA-linked hemochromatosis in a Chinese woman.

Oliver M, Scully L, GUIRAUDON C, Adams P Dig Dis Sci. 1995; 40(7):1589-91.

PMID: 7628289 DOI: 10.1007/BF02285215.

Idiopathic haemochromatosis and HLA antigens in Italy: is A3 Bw35 HLA haplotype a marker for idiopathic haemochromatosis gene in north east regions?.

Piperno A, Fargion S, Panaiotopoulos N, Del Ninno E, Taddei M, Fiorelli G J Clin Pathol. 1986; 39(2):125-8.

PMID: 3485115 PMC: 499664. DOI: 10.1136/jcp.39.2.125.

A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA....

Simon M, Le Mignon L, Fauchet R, Yaouanq J, David V, Edan G Am J Hum Genet. 1987; 41(2):89-105.

PMID: 3475981 PMC: 1684230.