Augmentation of Antitumor Resistance by a Strain of Unicellular Green Algae, Chlorella Vulgaris

Overview

Journal Cancer Immunol Immunother

Specialties Allergy & Immunology
Oncology
Pharmacology

Date 1984 Jan 1

PMID 6565519

Citations 13

Authors

K Tanaka

F Konishi

K Himeno

K Taniguchi

K Nomoto

Affiliations

Soon will be listed here.

Abstract

Growth of Meth-A tumor in CDF1 mice was inhibited significantly by injection of a hot water extract of a strain of Chlorella vulgaris (CE) into the tumor or into the subcutaneous tissue near the tumor. The augmentation of resistance by CE may require the participation of T cells and macrophages, since it was abolished or reduced in athymic nude mice or mice treated with carrageenan, a macrophage blocker. Mice treated with CE exhibited antigen-specific augmented resistance against rechallenge with tumor. Moreover, the antitumor effect of CE was comparable with that of Corynebacterium parvum, but its mechanism of effect might be different.

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