Possible Interrelationship Between Vitamins E and B12 in the Disturbance in Methylmalonate Metabolism in Vitamin E Deficiency

Overview

Journal Biochem J

Specialty Biochemistry

Date 1978 Apr 15

PMID 656065

Citations 1

Authors

A S Pappu

P FATTERPAKER

A Sreenivasan

Affiliations

Soon will be listed here.

Abstract

1. The disturbance in 2-methylmalonate metabolism resulting in its increased urinary excretion observed in vitamin E deficiency is not caused by increased formation of methylmalonate from propionate as is evident from the activity of the enzyme propionyl-CoA carboxylase (EC 6.4.1.3), but can be traced to an impairment in the conversion of methylmalonate into succinate by the vitamin B12-requiring enzyme, methylmalonyl-CoA mutase (EC 5.4.99.2) in rat liver. 2. It is shown that the decrease in the activity of methylmalonyl-CoA mutase in vitamin E deficiency is not a consequence of a secondary vitamin B12 deficiency. Peroxidative destruction of the coenzyme in vitamin E deficiency was also ruled out. The results suggest a defect in the conversion of cyanocobalamin into its coenzyme form.

Citing Articles

Effect of vitamin E deficiency on lipid composition of CNS-myelin in the rat.

Pappu A, FATTERPAKER P, Sreenivasan A Experientia. 1980; 36(2):160-1.

PMID: 7371743 DOI: 10.1007/BF01953706.

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