HLA-linked Complement Polymorphisms (C2, BF) in Psoriasis

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1983 Jan 1

PMID 6559061

Citations 5

Authors

G Dewald

C E Lange

E Schmeel

H W Kreysel

Affiliations

Soon will be listed here.

Abstract

Starting from the known association between psoriasis and several HLA antigens and from the fact that the HLA chromosomal region contains the structural genes for at least three complement components, the authors have looked for an association between psoriasis and allotypes of C2 and BF. C2 and BF polymorphism were examined in 230 psoriatic patients. Two rare complement genes were found to be significantly increased when compared with controls: the frequency of the C2*2 gene was 0.061 among patients and 0.035 among controls (P less than 0.05); for BF*SO7, the frequencies were 0.0304 in patients and 0.0092 in controls (P less than 0.0005). The BF*F gene frequency, however, was significantly decreased among patients: 0.1196 vs. 0.1743 (P less than 0.01). The relative risks were 1.79 for the C2 2, 3.44 for the BF SO7, and 0.6 for the BF F gene product. From previous studies, it is known that these three complement alleles (C2*2, BF*SO7, BF*F) are in linkage disequilibrium with HLA alleles that have also been found increased or decreased, respectively, in psoriasis.

Citing Articles

Discovering Genetic Factors for psoriasis through exhaustively searching for significant second order SNP-SNP interactions.

Lee K, Leung K, Tang N, Wong M Sci Rep. 2018; 8(1):15186.

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DNA polymorphism of the C2 locus.

Bentley D, Campbell R, Cross S Immunogenetics. 1985; 22(4):377-90.

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DNA polymorphism of the C2 and factor B genes. Detection of a restriction fragment length polymorphism which subdivides haplotypes carrying the C2C and factor B F alleles.

Cross S, Edwards J, Bentley D, Campbell R Immunogenetics. 1985; 21(1):39-48.

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Correlation between HLA-A2-Bw46-DRw8 haplotype and increased levels of complement components (C4 and C4a) in patients with psoriatic arthritis.

Muto M, Mashimo M, Urabe K, Suzuki T, Sasazuki T Arch Dermatol Res. 1991; 283(5):347-9.

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Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis.

Nakagawa H, Akazaki S, Asahina A, Tokunaga K, Matsuki K, Kuwata S Arch Dermatol Res. 1991; 283(5):281-4.

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