Restoration by Levamisole of Immune Responses Suppressed in Tumor-bearing Mice

Overview

Journal Cancer Immunol Immunother

Specialties Allergy & Immunology
Oncology
Pharmacology

Date 1983 Jan 1

PMID 6553512

Citations 1

Authors

M Shiraishi

K Himeno

K Nomoto

Affiliations

Soon will be listed here.

Abstract

Restorative effects of levamisole on suppressed immune responses were observed in BALB/c mice inoculated with a syngeneic methylcholanthrene-induced fibrosarcoma and immunized with nucleated chicken erythrocytes. In tumor-bearing mice, cell-mediated cytotoxicity, delayed footpad reaction, and antibodies were suppressed, and only the delayed footpad reaction was restored by levamisole. Suppressive effects in tumor-bearing mice can be transferred with sera or spleen cells, and the expression of suppressive effects cannot be abolished by treatment of the recipients with levamisole. However, the generation of suppressor mechanisms was affected by treatment of tumor-bearing donors with levamisole.

Citing Articles

Avirulent mutants of Macrophomina phaseolina and Aspergillus fumigatus initiate infection in Phaseolus mungo in the presence of phaseolinone; levamisole gives protection.

Sett S, Mishra S, Siddiqui K J Biosci. 2000; 25(1):73-80.

PMID: 10824201 DOI: 10.1007/BF02985184.

References

Hoebeke J, Franchi G . Influence of tetramisole and its optical isomers on the mononuclear phagocytic system. Effect on carbon clearance in mice. J Reticuloendothel Soc. 1973; 14(3):317-23. View

Hadden J, Coffey R, Hadden E, Sunshine G . Effects of levamisole and imidazole on lymphocyte proliferation and cyclic nucleotide levels. Cell Immunol. 1975; 20(1):98-103. DOI: 10.1016/0008-8749(75)90088-x. View

Verhaegen H, De Cock W, de Cree J, Verbruggen F, Brugmans J . Letter: In-vitro restoration by levamisole of thymus-derived lymphocyte functions in Hodgkin's disease. Lancet. 1975; 1(7913):978. DOI: 10.1016/s0140-6736(75)92040-1. View

PABST H, Crawford J . L-tetramisole. Enhancement of human lymphocyte response to antigen. Clin Exp Immunol. 1975; 21(3):468-73. PMC: 1538306. View

Sampson D, Peters T, Lewis J, Metzig J, Kurtz B . Dose dependence of immunopotentiation and tumor regression induced by levamisole. Cancer Res. 1977; 37(10):3526-9. View

Brugmans J, Schuermans V, De Cock W, THIENPONT D, Janssen P, Verhaegen H . Restoration of host defense mechanisms in man by levamisole. Life Sci. 1973; 13(11):1499-504. DOI: 10.1016/0024-3205(73)90137-9. View

Chirigos M, PEARSON J, Pryor J . Augmentation of chemotherapeutically induced remission of a murine leukemia by a chemical immunoadjuvant. Cancer Res. 1973; 33(11):2615-8. View

Rojas A, Feierstein J, Mickiewicz E, Glait H, OLIVARI A . Levamisole in advanced human breast cancer. Lancet. 1976; 1(7953):211-5. DOI: 10.1016/s0140-6736(76)91337-4. View

Webster D, Hughes L . Letter: Levamisole. Lancet. 1975; 1(7912):917-8. DOI: 10.1016/s0140-6736(75)91715-8. View

10.

Kubo C, Nomoto K, Sato M, Takeya K . Direct cytotoxicity against chicken erythrocytes in mice. I. Fundamental nature of T cell-mediated cytotoxicity. Immunology. 1977; 33(6):895-905. PMC: 1445549. View

11.

Holzman R, LAWRENCE H . Concentrations of levamisole required for enhanced proliferation of human lymphocytes and phagocytosis by macrophages. J Infect Dis. 1977; 135(4):517-23. DOI: 10.1093/infdis/135.4.517. View

12.

Ramot B, Biniaminov M, Shoham C, Rosenthal E . Effect of levamisole on E-rosette-forming cells in vivo and in vitro in Hodgkin's disease. N Engl J Med. 1976; 294(15):809-11. DOI: 10.1056/NEJM197604082941504. View

13.

WOODS W, Fliegleman M, Chirigos M . Effect of levamisole on the in vitro immune response of spleen lymphocytes. Proc Soc Exp Biol Med. 1975; 148(4):1048-50. DOI: 10.3181/00379727-148-38686. View

14.

Dinai Y, Pras M . Letter: Levamisole in rheumatoid arthritis. Lancet. 1975; 2(7934):556. DOI: 10.1016/s0140-6736(75)90934-4. View

15.

Levo Y, Rotter V, Ramot B . Restoration of cellular immune response by levamisole in patients with Hodgkin's disease. Biomedicine. 1975; 23(6):198-200. View

16.

Sadowski J, Rapp F . Inhibition by levamisole of metastases by cells transformed by herpes simplex virus type I. Proc Soc Exp Biol Med. 1975; 149(1):219-22. DOI: 10.3181/00379727-149-38776. View

17.

Mantovani A, Spreafico F . Allogeneic tumor enhancement by levamisole, a new immunostimulatory compound: studies on cell-mediated immunity and humoral antibody response. Eur J Cancer (1965). 1975; 11(8):537-44. DOI: 10.1016/0014-2964(75)90125-5. View

18.

Chan S, SIMONS M . Letter: Levamisole and lymphocyte responsiveness. Lancet. 1975; 1(7918):1246-7. DOI: 10.1016/s0140-6736(75)92243-6. View

19.

Renoux G, Renoux M . Modulation of immune reactivity by phenylimidothiazole salts in mice immunized by sheep red blood cells. J Immunol. 1974; 113(3):779-90. View

20.

de Cree J, Verhaegen H, De Cock W, VANHEULE R, Brugmans J, Schuermans V . Letter: Impaired neutrophil phagocytosis. Lancet. 1974; 2(7875):294-5. DOI: 10.1016/s0140-6736(74)91464-0. View