Differentiation of F9 Teratocarcinoma Stem Cells After Transfer of C-fos Proto-oncogenes

Overview

Journal Nature

Specialty Science

Date 1984 Oct 4

PMID 6541297

Citations 62

Authors

R Muller

E F Wagner

Affiliations

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Abstract

Transfer of mouse or human c-fos proto-oncogenes into F9 teratocarcinoma stem cells results in expression of c-fos mRNA and protein. This is accompanied by the appearance of morphologically altered cells which express several specific markers characteristic of differentiated cells, suggesting that c-fos plays a role in cellular differentiation.

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