Central and Peripheral Contrast Sensitivity in Amblyopia with Varying Field Size

Overview

Journal Doc Ophthalmol

Specialty Ophthalmology

Date 1984 Dec 15

PMID 6525936

Citations 8

Authors

L M Katz

D M Levi

H E Bedell

Affiliations

Soon will be listed here.

Abstract

The purpose of the present study was to establish the extent of the amblyopic deficit at 0 degree, 10 degrees, and 20 degrees retinal eccentricity using contrast sensitivity measures for sine wave gratings subtending various field sizes. Contrast sensitivity functions were shown to vary with stimulus field size, retinal location and degree of amblyopia. Foveally, peak contrast sensitivity of amblyopic eyes increased markedly with increasing field size, to reach the same magnitude as that of the contralateral non-amblyopic eyes for large fields. Peripherally, peak contrast sensitivity remained lower in the amblyopic eyes for all field sizes examined. High spatial frequency cut-offs were reduced both centrally and peripherally with all field sizes in the amblyopic eyes. The effect of increasing field size on the cut-off acuity was found to be smaller than the effect on peak contrast sensitivity. The most significant conclusions drawn from the results are that: (1) The amblyopic deficit in terms of both peak contrast sensitivity and acuity is not restricted to the central foveal region; and (2) amblyopic eyes benefit to a greater extent from increased stimulus field size than non-amblyopic eyes in terms of peak contrast sensitivity. A model is proposed which suggests that the results obtained are due to fewer and/or less sensitive cortical neurons being driven by the amblyopic eye in humans with naturally occurring amblyopia.

Citing Articles

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Exogenous attention generalizes location transfer of perceptual learning in adults with amblyopia.

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Sequential perceptual learning of letter identification and "uncrowding" in normal peripheral vision: Effects of task, training order, and cholinergic enhancement.

Levi D, Li R, Silver M, Chung S J Vis. 2020; 20(4):24.

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Amblyopia: New molecular/pharmacological and environmental approaches.

Stryker M, Lowel S Vis Neurosci. 2018; 35:E018.

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Spatial summation across the visual field in strabismic and anisometropic amblyopia.

Je S, Ennis F, Woodhouse J, Sengpiel F, Redmond T Sci Rep. 2018; 8(1):3858.

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