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Inhibition of Hepatic Uptake of Bile Acids by Rifamycins

Overview
Journal Naunyn Schmiedebergs Arch Pharmacol
Specialty Pharmacology
Date 1978 Mar 16
PMID 652048
Citations 7
Authors
M S Anwer
R Kroker
D HEGNER
Affiliations
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Abstract

The effect of rifamycin SV and rifampicin on hepatic acid uptake was studied using isolated rat hepatocytes in presence and in absence of albumin. The drugs inhibited cholate uptake more than taurocholate uptake and the inhibition was of non-competitive type. In presence of 3% albumin the inhibitory effect of the drugs was more for cholate and less for taurocholate uptake than in absence of albumin. Neither the binding of bile acids nor that of the drugs to albumin was altered by one another. Thus the effect in presence of albumin cannot be explained by the binding of the drugs and bile acids to albumin alone. It is suggested that albumin interacts with hepatic bile acid uptake process and this interaction with cholate uptake is different from that with taurocholate uptake. This additional and different effect of albumin may explain the effect of the drugs in presence of albumin. The results may be of clinical significance in rifamycins treatments.

Citing Articles

Influence of rifamycin SV on bile acid metabolism in rats.

Okolicsanyi L, Lirussi F, Nassuato G, Orlando R, Bussolon R, Dal Brun G Naunyn Schmiedebergs Arch Pharmacol. 1980; 313(2):171-4.

PMID: 7422017 DOI: 10.1007/BF00498576.

Comparative studies on the uptake of 14C-bile acids and 3H-demethylphalloin in isolated rat liver cells.

Petzinger E, Frimmer M Arch Toxicol. 1980; 44(1-3):127-35.

PMID: 7387395 DOI: 10.1007/BF00303189.

Rifampicin-induced elevation of serum bile acids in man.

Galeazzi R, Lorenzini I, Orlandi F Dig Dis Sci. 1980; 25(2):108-12.

PMID: 7353456 DOI: 10.1007/BF01308307.

Deformation of isolated rat hepatocytes by a peptide hepatotoxin from the blue-green alga microcystis aeruginosa.

Runnegar M, Falconer I, Silver J Naunyn Schmiedebergs Arch Pharmacol. 1981; 317(3):268-72.

PMID: 6798472 DOI: 10.1007/BF00503829.

Defective drug uptake contributing to multidrug resistance in hepatoma cells can be evaluated in vitro.

Buscher H Klin Wochenschr. 1990; 68(9):443-6.

PMID: 2162448 DOI: 10.1007/BF01648895.

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Anwer M, Kroker R, HEGNER D . Effect of albumin on bile acid uptake by isolated rat hepatocytes. Is there a common bile acid carrier?. Biochem Biophys Res Commun. 1976; 73(1):63-71. DOI: 10.1016/0006-291x(76)90497-6. View