Allergic Bronchopulmonary Aspergillosis (ABPA): Studies on the General and Specific Humoral Response

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 1978 Apr 14

PMID 652026

Citations 3

Authors

R S Sandhu

E J Bardana

Z U Khan

D M Dordevich

Affiliations

Soon will be listed here.

Abstract

Serum specimens from 138 patients suffering from chronic respiratory disorders including 63 with allergic bronchopulmonary aspergillosis (ABPA), 2o with suspected ABPA, 15 with pulmonary tuberculosis, 14 with bronchial asthma, 10 with chronic bronchitis and 6 with miscellaneous pulmonary conditions were studied for circulating antibodies to Aspergillus. The ammonium sulfate test was empolyed with an iodine-125 labeled mycelial component derived from Aspergillus fumigatus. When compared to normal controls from the same area, this test indicated that sera from 82 per cent of patients with ABPA had elevated binding titers to the radiolabeled antigenic component. Immunodiffusion using a culture filtrate antigen from A. fumigatus, revealed precipitating antibody to this fungus in 89 percent of sera from ABP patients. The majority of patients with ABPA demonstrated marked elevations of total serum IgE, moderate elevations of serum IgA and IgD and slightly increased levels of IgG and IgM.

Citing Articles

Serological diagnosis of pulmonary aspergillosis.

Sundaram S, KALYANASUNDARAM R, Rangaswamy V Mycopathologia. 1981; 75(2):93-9.

PMID: 6792543 DOI: 10.1007/BF00505784.

Aspergillus fumigatus-specific antibodies in allergic bronchopulmonary aspergillosis and aspergilloma: evidence for a polyclonal antibody response.

BRUMMUND W, Resnick A, Fink J, Kurup V J Clin Microbiol. 1987; 25(1):5-9.

PMID: 3539998 PMC: 265798. DOI: 10.1128/jcm.25.1.5-9.1987.

A guide to the recent literature on aspergillosis as caused by Aspergillus fumigatus, a fungus frequently found in self-heating organic matter.

MARSH P, Millner P, Kla J Mycopathologia. 1979; 69(1-2):67-81.

PMID: 396477 DOI: 10.1007/BF00428605.

References

JOHANSSON S, Bennich H, Wide L . A new class of immunoglobulin in human serum. Immunology. 1968; 14(2):265-72. PMC: 1409295. View

Bardana Jr E, Sobti K, Cianciulli F, Noonan M . Aspergillus antibody in patients with cystic fibrosis. Am J Dis Child. 1975; 129(10):1164-7. DOI: 10.1001/archpedi.1975.02120470020005. View

BROENNESTAM R, HALLBERG T . PRECIPITINS AGAINST AN ANTIGEN EXTRACT OF ASPERGILLUS FUMIGATUS IN PATIENTS WITH ASPERGILLOSIS OR OTHER PULMONARY DISEASES. Acta Med Scand. 1965; 177:385-92. View

Luster M, Leslie G, Bardana Jr E . Structure and biological functions of human IgD. VI. Serum IgD in patients with allergic bronchopulmonary aspergillosis. Int Arch Allergy Appl Immunol. 1976; 50(2):212-9. DOI: 10.1159/000231498. View

Waldman R, Mach J, Stella M, Rowe D . Secretory IgA in human serum. J Immunol. 1970; 105(1):43-7. View

Pepys J . Hypersensitivity diseases of the lungs due to fungi and organic dusts. Monogr Allergy. 1969; 4:1-147. View

Campbell M, Clayton Y . BRONCHOPULMONARY ASPERGILLOSIS. A CORRELATION OF THE CLINICAL AND LABORATORY FINDINGS IN 272 PATIENTS INVESTIGATED FOR BRONCHOPULMONARY ASPERGILLOSIS. Am Rev Respir Dis. 1964; 89:186-96. DOI: 10.1164/arrd.1964.89.2.186. View

Khan Z, Sandhu R, Randhawa H, Menon M, Dusaj I . Allergic bronchopulmonary aspergillosis: a study of 46 cases with special reference to laboratory aspects. Scand J Respir Dis. 1976; 57(2):73-87. View

Bardana Jr E . Measurement of humoral antibodies to aspergilli. Ann N Y Acad Sci. 1974; 221:64-75. DOI: 10.1111/j.1749-6632.1974.tb28200.x. View

10.

Sandhu R, Mishra S, Randhawa H, Parkash D . Allergic bronchopulmonary aspergillosis in India. Scand J Respir Dis. 1972; 53(5):289-301. View

11.

Bardana Jr E, McClatchy J, Farr R, MINDEN P . The primary interaction of antibody to components of aspergilli. I. Immunologic and chemical characteristics of a nonprecipitating antigen. J Allergy Clin Immunol. 1972; 50(4):208-21. DOI: 10.1016/0091-6749(72)90015-2. View

12.

Taylor B, NORMAN A, Orgel H, Stokes C, Turner M, Soothill J . Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973; 2(7821):111-3. DOI: 10.1016/s0140-6736(73)93060-2. View

13.

Kohler P, Farr R . Quantitative comparison of immunoglobulins in atopic (reaginic) and nonatopic (nonreaginic) individuals: higher gamma-D levels in atopic sera. J Allergy. 1967; 39(5):311-22. DOI: 10.1016/0021-8707(67)90095-0. View

14.

Katz R, KNIKER W . Infantile hypersensitivity pneumonitis as a reaction to organic antigens. N Engl J Med. 1973; 288(5):233-7. DOI: 10.1056/NEJM197302012880504. View

15.

Farr R, MINDEN P . Biology of the mycobacterioses. The measurement of antibodies. Ann N Y Acad Sci. 1968; 154(1):107-14. DOI: 10.1111/j.1749-6632.1968.tb16700.x. View

16.

LONGBOTTOM J, Pepys J . PULMONARY ASPERGILLOSIS: DIAGNOSTIC AND IMMUNOLOGICAL SIGNIFICANCE OF ANTIGENS AND C-SUBSTANCE IN ASPERGILLUS FUMIGATUS. J Pathol Bacteriol. 1964; 88:141-51. DOI: 10.1002/path.1700880119. View

17.

Mearns M, Longbottom J, Batten J . Precipitating antibodies to aspergillus fumigatus in cystic fibrosis. Lancet. 1967; 1(7489):538-9. DOI: 10.1016/s0140-6736(67)92115-0. View

18.

Slavin R, Laird T, Cherry J . Allergic bronchopulmonary aspergillosis in a child. J Pediatr. 1970; 76(3):416-21. DOI: 10.1016/s0022-3476(70)80482-6. View

19.

Ishizaka K . Gamma globulin and molecular mechanisms in hypersensitivity reactions. Prog Allergy. 1963; 7:32-106. View

20.

STALLYBRASS F . THE PRECIPITIN TEST IN HUMAN SYSTEMIC ASPERGILLOSIS. Mycopathol Mycol Appl. 1963; 21:272-8. DOI: 10.1007/BF02052580. View