Effect of Sodium Butyrate on Human Breast Carcinoma (MCF-7) Cellular Proliferation, Morphology, and CEA Production

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 1984 Jan 1

PMID 6518293

Citations 12

Authors

M Abe

D W Kufe

Affiliations

Soon will be listed here.

Abstract

Sodium butyrate is a potent inducer of leukemic cell differentiation. This agent also affects epithelial cell proliferation and gene expression. The present study demonstrates that sodium butyrate slows proliferation and induces morphologic changes in human MCF-7 breast carcinoma cells. The results also demonstrate that butyrate-treated MCF-7 cells have enhanced expression of carcinoembryonic antigen. These effects are related to butyrate concentration and duration of exposure. The present findings may provide a model for studying maturation of human breast cancer cells.

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