Effects of (-)-phenylephrine on Force of Contraction in the Presence of Cocaine and Hydrocortisone in Cat Papillary Muscle

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1984 Nov 1

PMID 6514019

Citations 1

Authors

A Mugge

C Reupcke

W Schmitz

H Scholz

Affiliations

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Abstract

The positive inotropic effect of (-)-phenylephrine, in the presence of propranolol, was studied after inhibition of neuronal and extraneuronal uptake in isolated papillary muscles from reserpine-pretreated cats. An inhibition of extraneuronal uptake with hydrocortisone influenced the effect of (-)-phenylephrine neither when present alone nor in the presence of cocaine (additional inhibition of neuronal uptake). An inhibition of neuronal uptake with cocaine caused a small but significant increase in the potency of (-)-phenylephrine. We conclude that in cat ventricular cardiac muscle the extraneuronal compartment is apparently neither a "site of loss" nor a "site of gain" for (-)-phenylephrine with respect to force of contraction.

Citing Articles

[Alpha-adrenoceptors in the myocardium: incidence and functional significance].

Mugge A Klin Wochenschr. 1985; 63(21):1087-97.

PMID: 3001400 DOI: 10.1007/BF02291089.

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