Postmortem Radiographic, Histological and Bacteriological Studies of Terminal Respiratory Infections and Other Pulmonary Lesions in Hospital and Non-hospital Necropsies

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1984 Nov 1

PMID 6501589

Citations 1

Authors

P Paakko

T Sarkioja

J Hirvonen

T Nurmi

R Lahti

S Sutinen

Affiliations

Soon will be listed here.

Abstract

One lung from 109 unselected hospital and 43 unselected non-hospital necropsies was studied using postmortem radiography with histological verification. Signs of acute bacterial infection, including bronchiolitis or bronchopneumonia, were present in 42.2% of the hospital necropsies and infection was the immediate cause of death in 8.3%. There was only one case of incipient bronchopneumonia among the non-hospital necropsies. Emphysema was the most common other pulmonary lesion in both groups. Gram negative bacteria were found significantly more often in the bronchial mucus of lungs with any pulmonary lesion, particularly those with signs of bacterial infection, than in the bronchial mucus of morphologically normal lungs in both groups of patients. In addition, the frequency of infections was associated with length of stay in hospital. This may reflect the prevalence of Gram negative infections in hospitals.

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References

Johanson W, Pierce A, SANFORD J . Changing pharyngeal bacterial flora of hospitalized patients. Emergence of gram-negative bacilli. N Engl J Med. 1969; 281(21):1137-40. DOI: 10.1056/NEJM196911202812101. View

MAYS B, Thomas G, Leonard Jr J, Southern Jr P, Pierce A, SANFORD J . Gram-negative bacillary necrotizing pneumonia: a bacteriologic and histopathologic correlation. J Infect Dis. 1969; 120(6):687-97. DOI: 10.1093/infdis/120.6.687. View

KONEMAN E, Minckler T, Shires D, de Jongh D . Postmortem bacteriology. II. Selection of cases for culture. Am J Clin Pathol. 1971; 55(1):17-23. DOI: 10.1093/ajcp/55.1.17. View

Thurlbeck W, Dunnill M, Hartung W, HEARD B, HEPPLESTON A, Ryder R . A comparison of three methods of measuring emphysema. Hum Pathol. 1970; 1(2):215-26. DOI: 10.1016/s0046-8177(70)80035-1. View

KONEMAN E, Davis M . Postmortem bacteriology. 3. Clinical significance of microorganisms recovered at autopsy. Am J Clin Pathol. 1974; 61(1):28-40. DOI: 10.1093/ajcp/61.1.28. View

Polednak A . Postmortem bacteriology and pneumonia in a mentally retarded population. Am J Clin Pathol. 1977; 67(2):190-5. DOI: 10.1093/ajcp/67.2.190. View

Valenti W, Trudell R, Bentley D . Factors predisposing to oropharyngeal colonization with gram-negative bacilli in the aged. N Engl J Med. 1978; 298(20):1108-11. DOI: 10.1056/NEJM197805182982002. View

Sutinen S, Vaajalahti P, Paakko P . Prevalence, severity, and types of pulmonary emphysema in a population of deaths in a Finnish city. Correlation with age, sex and smoking. Scand J Respir Dis. 1978; 59(2):101-15. View

Sutinen S, Paakko P, Lahti R . Post-mortem inflation, radiography, and fixation of human lungs. A method for radiological and pathological correlations and morphometric studies. Scand J Respir Dis. 1979; 60(1):29-35. View

10.

GERBER I . Terminal pneumonia in the aged. Mt Sinai J Med. 1980; 47(2):166-7. View

11.

Zanen H . Postmortem bacteriology of the lung by printculture of frozen tissue. A technique for in situ culture of microorganisms in whole frozen organs. J Clin Pathol. 1980; 33(5):474-80. PMC: 1146113. DOI: 10.1136/jcp.33.5.474. View

12.

Paakko P, Sutinen S, Lahti R . Pattern recognition in radiographs of excised air-inflated human lungs. II. Acute inflammation in non-emphysematous lungs. Eur J Respir Dis. 1981; 62(1):33-45. View

13.

Sutinen S, Paakko P, Lohela P, Lahti R . Pattern recognition in radiographs of excised air-inflated human lungs. IV Emphysema alone and with other common lesions. Eur J Respir Dis. 1981; 62(5):297-314. View

14.

Fedson D, Baldwin J . Previous hospital care as a risk factor for pneumonia. Implications for immunization with pneumococcal vaccine. JAMA. 1982; 248(16):1989-95. View

15.

Brumfitt W, WILLOUGHBY M, BROMLEY L . An evaluation of sputum examination in chronic bronchitis. Lancet. 1957; 273(7009):1306-9. DOI: 10.1016/s0140-6736(57)91637-9. View

16.

KNEELAND Jr Y, Price K . Antibiotics and terminal pneumonia. A postmortem microbiological study. Am J Med. 1960; 29:967-79. DOI: 10.1016/0002-9343(60)90077-2. View

17.

LAURENZI G, POTTER R, KASS E . Bacteriologic flora of the lower respiratory tract. N Engl J Med. 1961; 265:1273-8. DOI: 10.1056/NEJM196112282652601. View

18.

GORDON F, QUAN A . ISOLATION OF THE TRACHOMA AGENT IN CELL CULTURE. Proc Soc Exp Biol Med. 1965; 118:354-9. DOI: 10.3181/00379727-118-29841. View

19.

Lees A, MCNAUGHT W . Bacteriology of lower-respiratory-tract secretions, sputum, and upper-respiratory-tract secretions in "normals" and chronic bronchitics. Lancet. 1959; 2(7112):1112-5. DOI: 10.1016/s0140-6736(59)90099-6. View