Ethanol Diminishes the Toxicity of the Mushroom Amanita Phalloides

Overview

Journal Experientia

Specialty Science

Date 1984 Nov 15

PMID 6500014

Citations 2

Authors

G L FLOERSHEIM

L Bianchi

Affiliations

Soon will be listed here.

Abstract

Survival of mice after lethal doses of a lyophilizate from Amanita phalloides ('death cap') was markedly increased by single doses of ethanol applied 30 min before or 5 min after the mushroom. Hepatic histopathological damage (confluent necrosis) was largely prevented. Acute, but not chronic, consumption of ethanol may thus influence favorably the outcome of death cap poisoning and should be taken into consideration in the evaluation of therapeutic measures.

Citing Articles

[Mushroom poisonings: syndromic diagnosis and treatment].

Kaufmann P Wien Med Wochenschr. 2007; 157(19-20):493-502.

PMID: 18030554 DOI: 10.1007/s10354-007-0465-z.

Treatment of human amatoxin mushroom poisoning. Myths and advances in therapy.

FLOERSHEIM G Med Toxicol. 1987; 2(1):1-9.

PMID: 3547003 DOI: 10.1007/BF03259857.

References

Rubin E, Gang H, Misra P, Lieber C . Inhibition of drug metabolism by acute ethanol intoxication. A hepatic microsomal mechanism. Am J Med. 1970; 49(6):801-6. DOI: 10.1016/s0002-9343(70)80061-4. View

FLOERSHEIM G . [Experimental basis for the therapy of Amanita phalloides poisoning]. Schweiz Med Wochenschr. 1978; 108(6):185-97. View

FLOERSHEIM G . Ethanol and tolerated doses of Amanita phalloides protect against lethal doses of the mushroom. Agents Actions. 1977; 7(1):171-3. DOI: 10.1007/BF01964916. View

Chin J, Goldstein D . Effects of low concentrations of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes. Mol Pharmacol. 1977; 13(3):435-41. View

Sato C, Nakano M, Lieber C . Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity. J Pharmacol Exp Ther. 1981; 218(3):805-10. View

Harris R, Schroeder F . Ethanol and the physical properties of brain membranes: fluorescence studies. Mol Pharmacol. 1981; 20(1):128-37. View

Critchley J, Dyson E, Scott A, Jarvie D, Prescott L . Is there a place for cimetidine or ethanol in the treatment of paracetamol poisoning?. Lancet. 1983; 1(8338):1375-6. DOI: 10.1016/s0140-6736(83)92150-5. View

Sato C, Lieber C . Mechanism of the preventive effect of ethanol on acetaminophen-induced hepatoxicity. J Pharmacol Exp Ther. 1981; 218(3):811-5. View

Strubelt O, Obermeier F, Siegers C . The influence of ethanol pretreatment on the effects of nine hepatotoxic agents. Acta Pharmacol Toxicol (Copenh). 1978; 43(3):211-8. DOI: 10.1111/j.1600-0773.1978.tb02257.x. View

10.

Rubin E, Lieber C . Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol. Science. 1968; 162(3854):690-1. DOI: 10.1126/science.162.3854.690. View

11.

Traiger G, Plaa G . Relationship of alcohol metabolism to the potentiation of CCl 4 hepatotoxicity induced by aliphatic alcohols. J Pharmacol Exp Ther. 1972; 183(3):481-8. View

12.

FLOERSHEIM G, Eberhard M, Tschumi P, DUCKERT F . Effects of penicillin and silymarin on liver enzymes and blood clotting factors in dogs given a boiled preparation of Amanita phalloides. Toxicol Appl Pharmacol. 1978; 46(2):455-62. DOI: 10.1016/0041-008x(78)90091-1. View

13.

Sato C, Matsuda Y, Lieber C . Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat. Gastroenterology. 1981; 80(1):140-8. View

14.

Hasumura Y, Teschke R, Lieber C . Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption. Gastroenterology. 1974; 66(3):415-22. View

15.

FLOERSHEIM G, Weber O, Tschumi P, Ulbrich M . [Clinical death-cap (Amanita phalloides) poisoning: prognostic factors and therapeutic measures. Analysis of 205 cases]. Schweiz Med Wochenschr. 1982; 112(34):1164-77. View