Prospective Study of Early Rheumatoid Arthritis. II. Association of Rheumatoid Factor Isotypes with Fluctuations in Disease Activity

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1984 Oct 1

PMID 6497460

Citations 29

Authors

R H Withrington

I Teitsson

H Valdimarsson

M H Seifert

Affiliations

Soon will be listed here.

Abstract

Thirty-three patients with early peripheral synovitis were followed up for two to four years in order to study the relationship between fluctuations in rheumatoid factor (RF) levels and indices of clinical activity. Twenty-eight of these patients developed classical/definite rheumatoid arthritis (RA). Seventeen patients developed erosive disease of their hands and wrists and thirteen had a positive RF agglutination test. Nineteen patients had raised levels of IgM, RF, IgA, RF, or IgG RF as measured by isotype-specific ELISA techniques. The within-patient fluctuations in IgA RF levels correlated significantly with the corresponding fluctuations in grip strength (p less than 0.05), erythrocyte sedimentation rate (ESR) (p less than 0.01), and a composite index of disease activity (p less than 0.02). IgG RF levels were also associated with changes in ESR and grip strength, but IgM RF showed only a weak association with fluctuations in ESR and not with any other clinical parameters. It is suggested that serum IgA RF may be a useful marker of disease activity in rheumatoid arthritis.

Citing Articles

Rheumatoid Factor Titer as an Indicator of the Risk of Rheumatoid Arthritis Activity: Dose-Effect Analysis with the Restricted Cubic Spline Model.

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The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach.

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The Clinical Value of Autoantibodies in Rheumatoid Arthritis.

Bugatti S, Manzo A, Montecucco C, Caporali R Front Med (Lausanne). 2018; 5:339.

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Is rheumatoid arthritis a disease that starts in the intestine? A pilot study comparing an elemental diet with oral prednisolone.

Podas T, Nightingale J, Oldham R, Roy S, Sheehan N, Mayberry J Postgrad Med J. 2007; 83(976):128-31.

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Effects of rheumatoid factor isotypes on disease activity and severity in patients with rheumatoid arthritis: a comparative study.

Ates A, Kinikli G, Turgay M, Akay G, Tokgoz G Clin Rheumatol. 2006; 26(4):538-45.

PMID: 16804738 DOI: 10.1007/s10067-006-0343-x.

References

Ritchie D, Boyle J, McInnes J, Jasani M, Dalakos T, Grieveson P . Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968; 37(147):393-406. View

Winchester R, Agnello V, KUNKEL H . Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels. Clin Exp Immunol. 1970; 6(5):689-706. PMC: 1712723. View

Munthe E, Natvig J . Immunglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cells. Clin Exp Immunol. 1972; 12(1):55-70. PMC: 1553640. View

Finnie A, Mason M, Muir C . Evaluation of the RAHA test for rheumatoid factor. Med Lab Technol. 1974; 31(4):323-6. View

MASI A, Kaplan S, Feigenbaum S, Chandler R . Prospective study of the early course of rheumatoid arthritis in young adults: comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome. Semin Arthritis Rheum. 1976; 4(4):299-326. DOI: 10.1016/0049-0172(76)90013-5. View

Brook A, Corbett M . Radiographic changes in early rheumatoid disease. Ann Rheum Dis. 1977; 36(1):71-3. PMC: 1006633. DOI: 10.1136/ard.36.1.71. View

Carson D, Lawrance S, Catalano M, Vaughan J, Abraham G . Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG. J Immunol. 1977; 119(1):295-300. View

Dunne J, Carson D, Spiegelberg H, Alspaugh M, Vaughan J . IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjögren's syndrome. Ann Rheum Dis. 1979; 38(2):161-5. PMC: 1000343. DOI: 10.1136/ard.38.2.161. View

Granfors K, Viljanen M, TIILIKAINEN A, Toivanen A . Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980; 141(4):424-9. DOI: 10.1093/infdis/141.4.424. View

10.

Male D, Roitt I, Hay F . Analysis of immune complexes in synovial effusions of patients with rheumatoid arthritis. Clin Exp Immunol. 1980; 39(2):297-306. PMC: 1538046. View

11.

Mallya R, Mace B . The assessment of disease activity in rheumatoid arthritis using a multivariate analysis. Rheumatol Rehabil. 1981; 20(1):14-7. DOI: 10.1093/rheumatology/20.1.14. View

12.

Wernick R, Merryman P, Jaffe I, ZIFF M . IgG and IgM rheumatoid factors in rheumatoid arthritis. Quantitative response to penicillamine therapy and relationship to disease activity. Arthritis Rheum. 1983; 26(5):593-8. DOI: 10.1002/art.1780260503. View

13.

Lessard J, Nunnery E, Cecere F, McDuffy S, Pope R . Relationship between the articular manifestations of rheumatoid arthritis and circulating immune complexes detected by three methods and specific classes of rheumatoid factors. J Rheumatol. 1983; 10(3):411-7. View

14.

Panayi G . Elisa studies in ankylosing spondylitis. Br J Rheumatol. 1983; 22(4 Suppl 2):119-21. DOI: 10.1093/rheumatology/xxii.suppl_2.119. View

15.

WRIGHT V, Neumann V, Shinebaum R, Cooke E . Pathogenesis of seronegative arthritis. Br J Rheumatol. 1983; 22(4 Suppl 2):29-32. DOI: 10.1093/rheumatology/xxii.suppl_2.29. View

16.

Ebringer A . The cross-tolerance hypothesis, HLA-B27 and ankylosing spondylitis. Br J Rheumatol. 1983; 22(4 Suppl 2):53-66. DOI: 10.1093/rheumatology/xxii.suppl_2.53. View

17.

Withrington R, Teitsson I, Seifert M, Valdimarsson H . Felty's syndrome associated with high levels of IgA rheumatoid factor. Ann Rheum Dis. 1984; 43(3):505-7. PMC: 1001380. DOI: 10.1136/ard.43.3.505. View

18.

ROPES M, BENNETT G, COBB S, JACOX R, JESSAR R . 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958; 9(4):175-6. View

19.

OTTEN H, BOERMA F . Significance of the Waaler-Rose test, streptococcal agagglutination, and antistreptolysin titre in the prognosis of rheumatoid arthritis. Ann Rheum Dis. 1959; 18(1):24-8. PMC: 1007373. DOI: 10.1136/ard.18.1.24. View

20.

KUNKEL H, MULLER-EBERHARD H, Fudenberg H, Tomasi T . Gamma globulin complexes in rheumatoid arthritis and certain other conditions. J Clin Invest. 1961; 40:117-29. PMC: 290696. DOI: 10.1172/JCI104224. View