Effects of Dark Rearing on Dendritic Spines in Layer IV of the Mouse Visual Cortex. A Quantitative Electron Microscopical Study

Overview

Journal J Anat

Specialty Anatomy & Histology

Date 1978 May 1

PMID 649498

Citations 13

Authors

M Freire

Affiliations

Soon will be listed here.

Abstract

The effect of visual deprivation on dendritic spines in the visual cortex layer IV of 19 days old mice was studied with the electron microscopy. From the serial ultrathin sections of the selected dendrites bearing spines the author has calculated the volume and surface area of dendritic spines, and also the surface area of their synaptic zones. Employing statistical methods he has demonstrated that visual deprivation produced a retarded development of some dendritic spines in dark reared mice. The fact that the smallest dendritic spines cannot be seen with the light microscope while the number of such small spines is larger in the dark reared mice can well explain the apparent reduction in the number of dendritic spines in deprived animals studied in Golgi impregnated material.

Citing Articles

Comparison of Golgi-Cox and Intracellular Loading of Lucifer Yellow for Dendritic Spine Density and Morphology Analysis in the Mouse Brain.

Walker C, Greathouse K, Liu E, Muhammad H, Boros B, Freeman C Neuroscience. 2022; 498:1-18.

PMID: 35752428 PMC: 9420811. DOI: 10.1016/j.neuroscience.2022.06.029.

Activity-dependent modulation of synapse-regulating genes in astrocytes.

Farhy-Tselnicker I, Boisvert M, Liu H, Dowling C, Erikson G, Blanco-Suarez E Elife. 2021; 10.

PMID: 34494546 PMC: 8497060. DOI: 10.7554/eLife.70514.

Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer's Disease.

Walker C, Herskowitz J Neuroscientist. 2020; 27(5):487-505.

PMID: 32812494 PMC: 8130863. DOI: 10.1177/1073858420945964.

Synaptic Connectivity in Medium Spiny Neurons of the Nucleus Accumbens: A Sex-Dependent Mechanism Underlying Apathy in the HIV-1 Transgenic Rat.

McLaurin K, Cook A, Li H, League A, Mactutus C, Booze R Front Behav Neurosci. 2018; 12:285.

PMID: 30524255 PMC: 6262032. DOI: 10.3389/fnbeh.2018.00285.

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome.

Sourial M, Cheng C, Doering L J Exp Pharmacol. 2016; 5:45-54.

PMID: 27186135 PMC: 4863540. DOI: 10.2147/JEP.S27044.

References

GYLLENSTEN L . Postnatal development of the visual cortex is darkness (mice). Acta Morphol Neerl Scand. 1959; 2:331-45. View

VENABLE J, COGGESHALL R . A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965; 25:407-8. PMC: 2106628. DOI: 10.1083/jcb.25.2.407. View

BENNETT E, Diamond M, KRECH D, ROSENZWEIG M . CHEMICAL AND ANATOMICAL PLASTICITY BRAIN. Science. 1964; 146(3644):610-9. DOI: 10.1126/science.146.3644.610. View

Valverde F . Aspects of cortical organization related to the geometry of neurons with intra-cortical axons. J Neurocytol. 1976; 5(8):509-29. DOI: 10.1007/BF01175566. View

Globus A, SCHEIBEL A . Synaptic loci on visual cortical neurons of the rabbit: the specific afferent radiation. Exp Neurol. 1967; 18(1):116-31. DOI: 10.1016/0014-4886(67)90093-3. View

Valverde F, Ruiz-Marcos A . Dendritic spines in the visual cortex of the mouse: introduction to a mathematical model. Exp Brain Res. 1969; 8(3):269-83. DOI: 10.1007/BF00234253. View

Vrensen G, de Groot D . The effect of dark rearing and its recovery on synaptic terminals in the visual cortex of rabbits. A quantitative electron microscopic study. Brain Res. 1974; 78(2):263-78. DOI: 10.1016/0006-8993(74)90551-4. View

Chow K, Spear P . Morphological and functional effects of visual deprivation on the rabbit visual system. Exp Neurol. 1974; 42(2):429-47. DOI: 10.1016/0014-4886(74)90036-3. View

Fifkova E . The effect of monocular deprivation on the synaptic contacts of the visual cortex. J Neurobiol. 1969; 1(3):285-94. DOI: 10.1002/neu.480010304. View

10.

Valverde F . Structural changes in the area striata of the mouse after enucleation. Exp Brain Res. 1968; 5(4):274-92. DOI: 10.1007/BF00235903. View

11.

Dyson S, Jones D . The morphological categorization of developing synaptic junctions. Cell Tissue Res. 1976; 167(3):363-71. DOI: 10.1007/BF00219148. View

12.

Ryugo R, Ryugo D, Killackey H . Differential effect of enucleation on two populations of layer V pyramidal cells. Brain Res. 1975; 88(3):554-9. DOI: 10.1016/0006-8993(75)90670-8. View

13.

Ryugo D, Ryugo R, Killackey H . Changes in pyramidal cell density consequent to vibrissae removal in the newborn rat. Brain Res. 1975; 96(1):82-7. DOI: 10.1016/0006-8993(75)90575-2. View

14.

CRAGG B . The development of synapses in kitten visual cortex during visual deprivation. Exp Neurol. 1975; 46(3):445-51. DOI: 10.1016/0014-4886(75)90118-1. View

15.

Mollgaard K, Diamond M, BENNETT E, ROSENZWEIG M, Lindner B . Quantitative synaptic changes with differential experience in rat brain. Int J Neurosci. 1971; 2(3):113-27. DOI: 10.3109/00207457109148764. View

16.

Valverde F . Rate and extent of recovery from dark rearing in the visual cortex of the mouse. Brain Res. 1971; 33(1):1-11. DOI: 10.1016/0006-8993(71)90302-7. View

17.

Fifkova E . Changes of axosomatic synapses in the visual cortex of monocularly deprived rats. J Neurobiol. 1970; 2(1):61-71. DOI: 10.1002/neu.480020106. View

18.

CRAGG B . Changes in visual cortex on first exposure of rats to light. Effect on synaptic dimensions. Nature. 1967; 215(5098):251-3. DOI: 10.1038/215251a0. View

19.

Globus A, SCHEIBEL A . The effect of visual deprivation on cortical neurons: a Golgi study. Exp Neurol. 1967; 19(3):331-45. DOI: 10.1016/0014-4886(67)90029-5. View

20.

Valverde F . Apical dendritic spines of the visual cortex and light deprivation in the mouse. Exp Brain Res. 1967; 3(4):337-52. DOI: 10.1007/BF00237559. View