Ultrastructural Characteristics of Hyperplastic Alterations in the Liver of Congenital Portacaval-shunt Rats

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1984 Oct 1

PMID 6487537

Citations 3

Authors

F J Vonnahme

L Dubuisson

R Kubale

R Klempnauer

M Grun

Affiliations

Soon will be listed here.

Abstract

A congenital portacaval shunt was discovered in five rats. In these animals the hepatic artery was the only blood vessel perfusing the liver; the portal vein was absent. The livers were small and mainly hypoplastic, but light microscopy revealed the occurrence of focal hyperplastic alterations and occasional hyperplastic nodules. TEM and SEM showed these areas to be composed of clustered hepatocytes, separated by widened intercellular spaces. The cell membranes carried numerous pleomorphic microvilli, and the cytoplasma contained densely packed mitochondria, some of which were giant sized. Liver cells in the centrilobular region were hypoplastic. Comparison with findings of experimental portacaval anastomosis suggest that in congenital-shunt animals, the overall hypoplasia of the liver with the formation of hyperplastic areas is a consequence of the lack of portal blood.

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References

Starzl T, Watanabe K, Porter K, Putnam C . Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet. 1976; 1(7964):821-5. DOI: 10.1016/s0140-6736(76)90477-3. View

Fisher B, Lee S, Fisher E, Saffer E . Liver regeneration following portacaval shunt. Surgery. 1962; 52:88-102. View

Marks C, Markey C, Dyer R, Vaupel M . An electron microscopic study of the effects of portacaval shunts on the ultrastructure of the rat liver after partial hepatectomy. Am J Surg. 1975; 129(2):156-62. DOI: 10.1016/0002-9610(75)90291-3. View

Grun M, Liehr H . Biological consequences of porta-caval collateral circulation. Significance of pancreatic venous blood. Acta Hepatogastroenterol (Stuttg). 1978; 25(2):89-96. View

Starzl T, Francavilla A, Porter K, Benichou J, Jones A . The effect of splanchnic viscera removal upon canine liver regeneration. Surg Gynecol Obstet. 1978; 147(2):193-207. PMC: 2728054. View

Olling S, Olsson R . Congenital absence of portal venous system in a 50-year-old woman. Acta Med Scand. 1974; 196(4):343-5. DOI: 10.1111/j.0954-6820.1974.tb01020.x. View

Weinbren K, Washington S . Hyperplastic nodules after portacaval anastomosis in rats. Nature. 1976; 264(5585):440-2. DOI: 10.1038/264440a0. View

BARRETT R, deLahunta A, Roenick W, HOFFER R, Coons F . Four cases of congenital portacaval shunt in the dog. J Small Anim Pract. 1976; 17(2):71-85. DOI: 10.1111/j.1748-5827.1976.tb06577.x. View

OUDEA P, Bismuth H . [EXPERIMENTAL PROTACAVAL ANASTOMOSIS IN NORMAL RATS. STUDY OF HEPATIC LESIONS BY MEANS OF ELECTRON MICROSCOPE]. Pathol Biol. 1965; 13:288-96. View

10.

Guest J, Ryan C, Benjamin I, Blumgart L . Portacaval transposition and subsequent partial hepatectomy in the rat: effects on liver atrophy, hypertrophy and regenerative hyperplasia. Br J Exp Pathol. 1977; 58(2):140-6. PMC: 2041272. View

11.

Weinbren K, Stirling G, Washington S . The development of a proliferative response in liver parenchyma deprived of portal blood flow. Br J Exp Pathol. 1972; 53(1):54-8. PMC: 2072376. View

12.

Broelsch C, Lee S, Charters 3rd A, Chandler J, Grambort D, Orloff M . Regeneration of liver isografts transplantation in continuity with splanchnic organs. Surg Forum. 1974; 25(0):394-6. View

13.

Grun M, Liehr H, Rasenack U . Liver volume influences early outcome after portacaval anastomosis. Acta Gastroenterol Belg. 1978; 41(9-10):527-38. View

14.

HERZ R, Sautter V, Robert F, BIRCHER J . The Eck fistula rat: definition of an experimental model. Eur J Clin Invest. 1972; 2(6):390-7. DOI: 10.1111/j.1365-2362.1972.tb00667.x. View

15.

Liehr H, Grun M, Thiel H . Hepatic blood flow and cardiac output after porta-caval anastomosis in the rat. Acta Hepatogastroenterol (Stuttg). 1976; 23(1):31-40. View

16.

Solt D, Hay J, Farber E . Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver. Cancer Res. 1977; 37(6):1686-91. View

17.

Dubuisson L, Bioulac P, Saric J, Balabaud C . Hepatocyte ultrastructure in rats with portacaval shunt. A morphometric study of acinar zones. Dig Dis Sci. 1982; 27(11):1003-10. DOI: 10.1007/BF01391746. View

18.

Pouyet M, Berard P, Ruckebusch Y, GRIVEL M, Bousquet G, VAUZELLE J . [Selective portohepatic shunt. Pancreatic origin of the portal hepatotrophic factor]. Ann Chir. 1969; 23(7):393-402. View

19.

Audell L, Jonsson L, Lannek B . Congenital porta-caval shunts in the dog; a description of three cases. Zentralbl Veterinarmed A. 1974; 21(10):797-805. DOI: 10.1111/j.1439-0442.1974.tb01340.x. View

20.

HELLWEG G . Congenital absence of intrahepatic portal venous system simulating Eck fistula; report of a case with necropsy findings. AMA Arch Pathol. 1954; 57(5):425-30. View