Natural Killer Activity of Kurloff Cells: a Direct Demonstration on Purified Kurloff Cell Suspensions

Overview

Journal Cell Immunol

Publisher Elsevier

Specialties Allergy & Immunology
Cell Biology

Date 1984 Sep 1

PMID 6467387

Citations 8

Authors

C Debout

M Quillec

J Izard

Affiliations

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Abstract

In order to study their natural killer effect, guinea pig splenic Kurloff cells were fractionated by Percoll discontinuous density gradient centrifugation. Kurloff cells were collected and tested for cytotoxicity in a 24-hr chromium-release test. Comparison of different splenic cellular samples (of males or estrogenized females) with increasing percentage of Kurloff cells, revealed a highly significant positive correlation (r = 0.93, alpha less than 0.01) with the cellular cytotoxicity developed against the K 562 target cells.

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