Rheumatoid Synovial Cells in Culture Produce a Growth Inhibitor

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1978 Apr 1

PMID 646470

Citations 1

Authors

C A Smith

Affiliations

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Abstract

Cultures of synovial cells obtained at surgery from patients with rheumatoid arthritis produced a protein which inhibits the mitosis of normal rabbit and human synovial cells, and of human lung fibroblasts. This mitotic inhibitory effect can be transferred to rabbit synovial cells by intra-articular injection of the animals with rheumatoid synovial cell cultures.

Citing Articles

Some in-vitro comparisons of synovial cells dispersed by trypsin from rheumatoid and nonrheumatoid synovium.

Clarris B, Fraser J, Stanley J Ann Rheum Dis. 1981; 40(3):286-92.

PMID: 7247472 PMC: 1000764. DOI: 10.1136/ard.40.3.286.

References

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Patterson R, Peterson D, Deinhardt F, Howard F . Rubella and rheumatoid arthritis: hyaluronic acid and susceptibility of cultured rheumatoid synovial cells to viruses. Proc Soc Exp Biol Med. 1975; 149(3):594-8. DOI: 10.3181/00379727-149-38859. View

Smith C, Hamerman D, Janis R, Habermann E . Virus resistance transferred from human rheumatoid cells to rabbit synovial cells. I. Methods and results of intra-articular injection of human cells into rabbit joints. Ann Rheum Dis. 1974; 33(2):173-9. PMC: 1006235. DOI: 10.1136/ard.33.2.173. View

Smith C, Hamerman D . Significance of persistent differences between normal and rheumatoid synovial membrane cells in culture. Arthritis Rheum. 1969; 12(6):639-45. DOI: 10.1002/art.1780120612. View

Smith C . Properties of synovial cells in culture. J Exp Med. 1971; 134(3 Pt 2):306s-312s. View