Clinical Applications of Serum Theophylline Measurement by High Pressure Liquid Chromatography

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1978 Apr 1

PMID 646444

Citations 11

Authors

S A McKenzie

A T Edmunds

E Baillie

J H Meek

Affiliations

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Abstract

Serum theophylline concentration was measured in children both during treatment of status asthmaticus with intravenous aminophylline, and as outpatients while they were taking oral theophylline compounds for long-term management of asthma. The clinical value of the measurements was assessed. Measurement using high-pressure liquid chromatography is simple and requires only a small volume of blood. Knowledge of serum theophylline concentration facilitates careful control of dosage of both intravenous aminophylline during treatment of status asthmaticus, and of oral theophylline in outpatients. It is useful in the evaluation of symptoms which may be due to toxic side effects of treatment. It also makes possible an assessment of patient compliance with prescribed treatment among those whose symptoms have not improved.

Citing Articles

Cardiovascular response during severe acute asthma and its treatment in children.

Edmunds A, Godfrey S Thorax. 1981; 36(7):534-40.

PMID: 7314025 PMC: 1020437. DOI: 10.1136/thx.36.7.534.

Sustained release oral aminophylline in patients with airflow obstruction.

Greening A, Baillie E, Gribbin H, Pride N Thorax. 1981; 36(4):303-7.

PMID: 7025336 PMC: 471497. DOI: 10.1136/thx.36.4.303.

Drug level monitoring in paediatric practice.

Rylance G, Moreland T Arch Dis Child. 1980; 55(2):89-98.

PMID: 6990880 PMC: 1626686. DOI: 10.1136/adc.55.2.89.

Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid?.

Wilson N, Silverman M Br Med J (Clin Res Ed). 1982; 284(6319):863-6.

PMID: 6802327 PMC: 1496292. DOI: 10.1136/bmj.284.6319.863.

Lack of influence of an intensive antacid regimen on theophylline bioavailability.

Reed R, Schwartz H J Pharmacokinet Biopharm. 1984; 12(3):315-31.

PMID: 6502473 DOI: 10.1007/BF01061723.

References

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