Vascular Tumors of the Mammary Gland. A Histochemical and Ultrastructural Study

Overview

Journal Virchows Arch A Pathol Anat Histol

Specialty Pathology

Date 1981 Jan 1

PMID 6461125

Citations 2

Authors

E Alvarez-Fernandez

E Salinero-Paniagua

Affiliations

Soon will be listed here.

Abstract

A total of five haemangiosarcomata and two benign haemangiomas arising in the mammary gland have been studied electron microscopically and by histochemical techniques. Malignant tumors were mainly composed of endothelial cells reactive to alkaline phosphatase and adenosine triphosphatase, and of pericytes and undifferentiated mesenchymal elements. A juvenile haemangioma showed a more structured wall with an increase of endoplasmic reticulum and filaments, and a diminution of membrane modulations and rod-like tubular bodies. A cavernous haemangioma showed an ultrastructure very similar to normal vessels. The ultrastructural and histochemical data suggest a blood vessel origin of mammary angiosarcomas and show that vascular neoplasms of the breast, benign or malignant, are composed of a combined proliferation of the different cell types present in the vessel wall, as described in other organs.

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