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Paternal Age and Down's Syndrome: Data from Prenatal Diagnoses (DFG)

Overview
Journal Hum Genet
Specialty Genetics
Date 1981 Jan 1
PMID 6459986
Citations 24
Authors
J Stene
E Stene
S Stengel-Rutkowski
J D MURKEN
Affiliations
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Abstract

From prenatal diagnosis data obtained on mothers aged 35 years and above in the Federal Republic of Germany (DFG data), older fathers are demonstrated to have an increased risk of having trisomy 21 offspring. For paternal ages of 41 years upward, the age effect is quite strong. The risk for a fetus to have any de novo chromosomal aberration increases more with advancing paternal age for older mothers than for younger ones. Thus the ages of both parents have to be taken into account as an indication for prenatal diagnosis. Risk figures for trisomy 21 and for any de novo chromosomal aberration are given, together with preliminary recommendations for prenatal diagnosis for different combinations of parental ages.

Citing Articles

Are paternal or grandmaternal age associated with higher probability of trisomy 21 in offspring? A population-based, matched case-control study, 1995-2015.

Schliep K, Feldkamp M, Hanson H, Hollingshaus M, Fraser A, Smith K Paediatr Perinat Epidemiol. 2020; 35(3):281-291.

PMID: 33258505 PMC: 8058293. DOI: 10.1111/ppe.12737.

High percentages of embryos with 21, 18 or 13 trisomy are related to advanced paternal age in donor egg cycles.

Garcia-Ferreyra J, Hilario R, Duenas J JBRA Assist Reprod. 2018; 22(1):26-34.

PMID: 29303233 PMC: 5844656. DOI: 10.5935/1518-0557.20180004.

An unexpected finding: younger fathers have a higher risk for offspring with chromosomal aneuploidies.

Steiner B, Masood R, Rufibach K, Niedrist D, Kundert O, Riegel M Eur J Hum Genet. 2014; 23(4):466-72.

PMID: 25005732 PMC: 4666566. DOI: 10.1038/ejhg.2014.122.

Parental-age effects in Down syndrome.

Girirajan S J Genet. 2009; 88(1):1-7.

PMID: 19417538 DOI: 10.1007/s12041-009-0001-6.

Periodic health examination, 1996 update: 1. Prenatal screening for and diagnosis of Down syndrome. Canadian Task Force on the Periodic Health Examination.

Dick P CMAJ. 1996; 154(4):465-79.

PMID: 8630836 PMC: 1487598.

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