Ia+ T Cells in Synovial Fluid and Tissues of Patients with Rheumatoid Arthritis

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1981 Nov 1

PMID 6459096

Citations 90

Authors

G R Burmester

D T Yu

A M Irani

H G KUNKEL

R J Winchester

Affiliations

Soon will be listed here.

Abstract

Markedly elevated levels of T cells expressing Ia antigens were found in the synovial membranes and synovial fluids of patients with rheumatoid arthritis. The primary increase in expression of the Ia antigens was on the OKT 8+ (suppressor/cytotoxic) T cell subset. In addition, the total percentage of OKT 8+ T cells in intraarticular sites was usually greater than levels in peripheral blood. Small numbers of OKT 4+ (helper/inducer) cells bearing Ia antigens were also identified. The characteristic increase in the Ia+ T cells in peripheral blood was not encountered in most patients treated with D-penicillamine.

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