Immunoregulation and Anti-nuclear Antibodies in Mercury-induced Glomerulopathy in the Rat

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1981 Jul 1

PMID 6458435

Citations 7

Authors

J J Weening

P J HOEDEMAEKER

W W Bakker

Affiliations

Soon will be listed here.

Abstract

The pathogenesis of drug-induced autoimmune antibodies is in most cases uncertain. The recent demonstration of T cell aberrations in human and experimental drug-induced autoimmune disease suggests that immunodysregulation might form the basis of an uncontrolled B cell autoreactivity leading to autoantibody production. In the present study, lymphocytic stimulation by phytohemagglutinin (PHA) and concanavalin A-activated suppressor cell activity was measured in an experimental model of mercury-induced immune complex glomerulopathy associated with anti-nuclear antibodies and vasculitis in PVG/c rats. Both general T cell reactivity to PHA and concanavalin A-activated suppressor function as measured by a syngeneic target cell assay were found to be significantly decreased in mercury-diseased rats as compared with saline-injected control rats. Furthermore, the effect of neonatal and adult thymectomy on the course of the mercury-induced disease was studied. Anti-nuclear antibody activity and glomerular immune aggregate formation were found to be accelerated considerably by neonatal thymectomy, whereas thymectomy at adult age had no significant effect on the interval between the start of mercury administration and the appearance of serological and renal abnormalities. From the results it is concluded that mercury affects both effector and regulatory T cell functions and that immunodysregulation seems to be of pathogenetic significance in this model of drug-induced disease.

Citing Articles

Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study.

Dahlgren J, Takhar H, Anderson-Mahoney P, Kotlerman J, Tarr J, Warshaw R Environ Health. 2007; 6:8.

PMID: 17316448 PMC: 1821321. DOI: 10.1186/1476-069X-6-8.

Immunologically mediated glomerulonephritis induced by heavy metals.

Druet P, Bernard A, Hirsch F, Weening J, GENGOUX P, Mahieu P Arch Toxicol. 1982; 50(3-4):187-94.

PMID: 6756345 DOI: 10.1007/BF00310850.

Experimental mercury-induced glomerulonephritis.

Pelletier L, Hirsch F, Rossert J, Druet E, Druet P Springer Semin Immunopathol. 1987; 9(4):359-69.

PMID: 3324367 DOI: 10.1007/BF00197214.

Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression.

Aten J, Bosman C, Rozing J, Stijnen T, HOEDEMAEKER P, Weening J Am J Pathol. 1988; 133(1):127-38.

PMID: 3052091 PMC: 1880643.

Induction of anti-nuclear antibodies in mice orally exposed to cadmium at low concentrations.

Ohsawa M, Takahashi K, Otsuka F Clin Exp Immunol. 1988; 73(1):98-102.

PMID: 3048815 PMC: 1541480.

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