Alpha 2.0
Login Register
» Articles » PMID: 6454785

Temporal Increase in the Rate of Down Syndrome Livebirths to Older Mothers in New York State

Overview
Journal J Med Genet
Specialty Genetics
Date 1981 Feb 1
PMID 6454785
Citations 8
Authors
E B Hook
P K Cross
Affiliations
Soon will be listed here.
Abstract

In New York State exclusive of New York City the standardised rate of Down syndrome in livebirths to women 35 and over reported on birth certificates increased 30% in 1970 and later years, compared to the rate in 1965 and 1969. In contrast, there was no change in those under 35. A separate investigation revealed that selective temporal differences in reporting of cases born to older mother did not account for the change. A similar increase in rates of cases born to older but not younger mothers in 1970 and later years has also been reported from Manitoba. These observations may be pertinent to apparent discrepancies between livebirth rates of Down syndrome and those reported at amniocentesis.

Citing Articles

Rates of trisomies 21, 18, 13 and other chromosome abnormalities in about 20 000 prenatal studies compared with estimated rates in live births.

Schreinemachers D, Cross P, Hook E Hum Genet. 1982; 61(4):318-24.

PMID: 6891368 DOI: 10.1007/BF00276595.

Down's syndrome: percentage reporting on birth certificates and single year maternal age risk rates for Ohio 1970-79: comparison with upstate New York data.

Huether C, Gummere G, Hook E, Dignan P, Volodkevich H, Barg M Am J Public Health. 1981; 71(12):1367-72.

PMID: 6459034 PMC: 1619954. DOI: 10.2105/ajph.71.12.1367.

Spontaneous abortion and subsequent Down syndrome livebirth.

Hook E, Cross P Hum Genet. 1983; 64(3):267-70.

PMID: 6224736 DOI: 10.1007/BF00279407.

The incidence of Down's syndrome over a 19-year period with special reference to maternal age.

Owens J, Harris F, Walker S, McAllister E, West L J Med Genet. 1983; 20(2):90-3.

PMID: 6221104 PMC: 1049005. DOI: 10.1136/jmg.20.2.90.

Paternal age and Down's syndrome genotypes diagnosed prenatally: no association in New York state data.

Hook E, Cross P Hum Genet. 1982; 62(2):167-74.

PMID: 6219060 DOI: 10.1007/BF00282309.

References
1.
Evans J, Hunter A, Hamerton J . Down syndrome and recent demographic trends in Manitoba. J Med Genet. 1978; 15(1):43-7. PMC: 1012822. DOI: 10.1136/jmg.15.1.43. View
2.
Ferguson-Smith M . Maternal age and Down syndrome. Lancet. 1978; 2(8082):213. DOI: 10.1016/s0140-6736(78)91958-x. View
3.
Hook E . Spontaneous deaths of fetuses with chromosomal abnormalities diagnosed prenatally. N Engl J Med. 1978; 299(19):1036-8. DOI: 10.1056/NEJM197811092991903. View
4.
Hook E . Differences between rates of trisomy 21 (Down syndrome) and other chromosomal abnormalities diagnosed in livebirths and in cells cultured after second-trimester amniocentesis--suggested explanations and implications for genetic counseling and.... Birth Defects Orig Artic Ser. 1978; 14(6C):249-67. View
5.
Sutherland G, Clisby S, Bloor G, Carter R . Down's syndrome in South Australia. Med J Aust. 1979; 2(2):58-61. DOI: 10.5694/j.1326-5377.1979.tb112703.x. View