Serotoninergic Modulation of Mesolimbic and Frontal Cortical Dopamine Neurons

Overview

Journal Experientia

Specialty Science

Date 1980 Sep 15

PMID 6448165

Citations 3

Authors

P C Waldmeier

Affiliations

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Abstract

Potentiation of the effect of haloperidol on dopamine metabolism by the 5-HT uptake inhibitor CGP 6085 A, and antagonism of this effect by the 5-HT antagonist mianserin were observed in the mesolimbic area and the frontal cortex of the rat brain. A similar effect was reported earlier in the corpus striatum. This suggests that serotoninergic modulation of dopamine neurons is a generally-occurring phenomenon in the brain.

Citing Articles

Effects of CGP 11305 A, a new reversible and selective inhibitor of MAO A, on biogenic amine levels and metabolism in the rat brain.

Waldmeier P, Baumann P Naunyn Schmiedebergs Arch Pharmacol. 1983; 324(1):20-6.

PMID: 6195533 DOI: 10.1007/BF00647833.

Modulation of dopaminergic transmission by alpha-noradrenergic agonists and antagonists: evidence for antidopaminergic properties of some alpha antagonists.

Waldmeier P, ORTMANN R, Bischoff S Experientia. 1982; 38(10):1168-76.

PMID: 6128245 DOI: 10.1007/BF01959727.

Clinical and biochemical effects of citalopram, a selective 5-HT reuptake inhibitor--a dose-response study in depressed patients.

Bjerkenstedt L, Edman G, Flyckt L, Hagenfeldt L, Sedvall G, Wiesel F Psychopharmacology (Berl). 1985; 87(3):253-9.

PMID: 3936081 DOI: 10.1007/BF00432703.

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