Delayed Hypersensitivity in Man: Effects of Systemic Anticoagulation

Overview

Journal Science

Specialty Science

Date 1978 May 5

PMID 644314

Citations 20

Authors

R L Edwards

F R Rickles

Affiliations

Soon will be listed here.

Abstract

Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte trnasformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans.

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