Dose-dependent Change in Tissue Uptake of 17 Beta-(16 Alpha-[125I]iodo)-estradiol in Female Rats: Application to External Imaging of Mammary Carcinoma

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1984 Jan 1

PMID 6440788

Authors

S Noguchi

H Koyama

S Nakano

Affiliations

Soon will be listed here.

Abstract

Recently, many studies have drawn attention to the possibility of imaging estrogen-receptor-positive breast cancer with a high-affinity ligand such as 17 beta-(16 alpha-[125I]iodo)-estradiol (I-E2). We tried to determine the most suitable time and dose for imaging with this compound, using uteri of mature Sprague-Dawley rats. Although the uptake of I-E2 in the target organ (uterus) reached its peak 1 h after subcutaneous injection, the ratio of uptake in the target organ to that in nontarget organs (lung and muscle) peaked at 4 h. We also found that this ratio decreased as the dose increased. The clearest image was available 4 h after the dose meeting the minimum requirement for imaging was administered. An imaging trial of dimethylbenzanthracene (DMBA)-induced mammary carcinoma is also demonstrated.

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